Conditioned medium from stimulated mononuclear leucocytes potentiates the ability of human neutrophils do damage human articular cartilage

E. J. Bates, I. C. Kowanko, A. Ferrante

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Human neutrophils were able to degrade proteoglycan and inhibit its synthesis when incubated with human articular cartilage coated with heat aggregated immunoglobulin G. These effects were potentiated when culture medium conditioned by mononuclear leucocytes stimulated with killed Staphylococcus aureus was also present during the incubations. Neutrophils preincubated with this conditioned medium and washed before incubation with cartilage also showed an increased ability to degrade proteoglycan and inhibit its synthesis. The percentage of neutrophils binding to cartilage was significantly increased in the presence of this conditioned medium.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAnnals of the Rheumatic Diseases
Issue number1
Publication statusPublished or Issued - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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