TY - JOUR
T1 - Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology
AU - Ahmed, Muktar
AU - Mäkinen, Ville Petteri
AU - Mulugeta, Anwar
AU - Shin, Jisu
AU - Boyle, Terry
AU - Hyppönen, Elina
AU - Lee, Sang Hong
N1 - Funding Information:
The authors extend sincere thanks to the study participants of the UK biobank, who made this work possible. This study has been conducted using the UK Biobank Resource ( http://www.ukbiobank.ac.uk ) with the reference number 14575 & 20175 approved by UK Biobank. The High-Performance Computing (HPC) resources were provided by the Australian government through Gadi under the National Computational Merit Allocation Scheme (NCMAS) and by the University of South Australia through supercomputing clusters of Tango 2.0 and StatGen server. This work is supported by grants from the Australian Research Council (DP 190100766); Tour de Cure (RSP-013-18/19) and National Health and Medical Research Council, Australia (GT1157281).
Funding Information:
The authors extend sincere thanks to the study participants of the UK biobank, who made this work possible. This study has been conducted using the UK Biobank Resource (http://www.ukbiobank.ac.uk) with the reference number 14575 & 20175 approved by UK Biobank. The High-Performance Computing (HPC) resources were provided by the Australian government through Gadi under the National Computational Merit Allocation Scheme (NCMAS) and by the University of South Australia through supercomputing clusters of Tango 2.0 and StatGen server. This work is supported by grants from the Australian Research Council (DP 190100766); Tour de Cure (RSP-013-18/19) and National Health and Medical Research Council, Australia (GT1157281).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Hormone-related cancers, including cancers of the breast, prostate, ovaries, uterine, and thyroid, globally contribute to the majority of cancer incidence. We hypothesize that hormone-sensitive cancers share common genetic risk factors that have rarely been investigated by previous genomic studies of site-specific cancers. Here, we show that considering hormone-sensitive cancers as a single disease in the UK Biobank reveals shared genetic aetiology. We observe that a significant proportion of variance in disease liability is explained by the genome-wide single nucleotide polymorphisms (SNPs), i.e., SNP-based heritability on the liability scale is estimated as 10.06% (SE 0.70%). Moreover, we find 55 genome-wide significant SNPs for the disease, using a genome-wide association study. Pair-wise analysis also estimates positive genetic correlations between some pairs of hormone-sensitive cancers although they are not statistically significant. Our finding suggests that heritable genetic factors may be a key driver in the mechanism of carcinogenesis shared by hormone-sensitive cancers.
AB - Hormone-related cancers, including cancers of the breast, prostate, ovaries, uterine, and thyroid, globally contribute to the majority of cancer incidence. We hypothesize that hormone-sensitive cancers share common genetic risk factors that have rarely been investigated by previous genomic studies of site-specific cancers. Here, we show that considering hormone-sensitive cancers as a single disease in the UK Biobank reveals shared genetic aetiology. We observe that a significant proportion of variance in disease liability is explained by the genome-wide single nucleotide polymorphisms (SNPs), i.e., SNP-based heritability on the liability scale is estimated as 10.06% (SE 0.70%). Moreover, we find 55 genome-wide significant SNPs for the disease, using a genome-wide association study. Pair-wise analysis also estimates positive genetic correlations between some pairs of hormone-sensitive cancers although they are not statistically significant. Our finding suggests that heritable genetic factors may be a key driver in the mechanism of carcinogenesis shared by hormone-sensitive cancers.
UR - http://www.scopus.com/inward/record.url?scp=85132265246&partnerID=8YFLogxK
U2 - 10.1038/s42003-022-03554-y
DO - 10.1038/s42003-022-03554-y
M3 - Article
C2 - 35729236
AN - SCOPUS:85132265246
SN - 2399-3642
VL - 5
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 614
ER -