Correction to: Dodging silver bullets: Good CRISPR gene-drive design is critical for eradicating exotic vertebrates (Proceedings of the Royal Society B: Biological Sciences (2017 ) 284 (20170799) DOI: 10.1098/rspb.2017.0799)

We recently found an error in ourcalculation of the probabilityof a wild-type allele moving froms to j susceptible sites (P_sj), and acquiring the gene drive (Psg), during gene-drive homing, under the assumption thatmultiplexed gRNAs are expressed simultaneously. In the R code provided (function GeneDriveSimRec, appendix S1), these probabilities are calculated recursively and the multiplier (1-P_N)^j was missing (from line 11), where j is the number of cut target sites along an inter-site NHEJ-mediated deletion at which NHEJ did not occur. We have assessed the impact of this omission on our results, and it is negligible for the baseline of P_N = 0:02 used in our study. However, the impact of this error increases as PN increases. Therefore, we have redone the sensitivity analysis in which we tested P_N ranging up to 0.1. The amended figure 6 below is essentially identical to the original figure, with the exception that probabilities of eradication are slightly lower for P_N close to 0.1 in panel (c) of the corrected version.(Figure Persented).This same error invalidates the expression provided in the paper for the probability of successful homing (Psg) for a wild-type allele with s susceptible sites, assuming multiplexed gRNAs are expressed simultaneously. The original expression published was:(Equation Persented).