Cortical inhibition, excitation, and connectivity in schizophrenia: A review of insights from transcranial magnetic stimulation

Nigel C. Rogasch; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1093/schbul/sbt078

Cortical inhibition, excitation, and connectivity in schizophrenia: A review of insights from transcranial magnetic stimulation

Nigel C. Rogasch, Zafiris J. Daskalakis, Paul B. Fitzgerald

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/inhibition on cortical oscillations in SCZ.

Original language	English
Pages (from-to)	685-696
Number of pages	12
Journal	Schizophrenia Bulletin
Volume	40
Issue number	3
DOIs	https://doi.org/10.1093/schbul/sbt078
Publication status	Published or Issued - May 2014
Externally published	Yes

Keywords

GABA
NMDA
connectivity
cortical inhibition

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1093/schbul/sbt078

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abstract = "Schizophrenia (SCZ) is a debilitating mental illness with an elusive pathophysiology. Over the last decade, theories emphasizing cortical dysfunction have received increasing attention to explain the heterogeneous symptoms experienced in SCZ. Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation that is particularly suited to probing the fidelity of specific excitatory and inhibitory neuronal populations in conscious humans. In this study, we review the contribution of TMS in assessing inhibitory and excitatory neuronal populations and their long-range connections in SCZ. In addition, we discuss insights from combined TMS and electroencephalography into the functional consequences of impaired excitation/inhibition on cortical oscillations in SCZ.",

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AU - Fitzgerald, Paul B.

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KW - GABA

KW - NMDA

KW - connectivity

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ER -

Cortical inhibition, excitation, and connectivity in schizophrenia: A review of insights from transcranial magnetic stimulation

Abstract

Keywords

ASJC Scopus subject areas

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