Crosstalk between mTor Complexes

Jianling Xie; Christopher G. Proud

doi:10.1038/ncb2877

Crosstalk between mTor Complexes

Jianling Xie, Christopher G. Proud

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

Original language	English
Pages (from-to)	1263-1265
Number of pages	3
Journal	Nature Cell Biology
Volume	15
Issue number	11
DOIs	https://doi.org/10.1038/ncb2877
Publication status	Published or Issued - Nov 2013
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb2877

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title = "Crosstalk between mTor Complexes",

abstract = "The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.",

author = "Jianling Xie and Proud, \{Christopher G.\}",

year = "2013",

month = nov,

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journal = "Nature Cell Biology",

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AU - Proud, Christopher G.

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AB - The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

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U2 - 10.1038/ncb2877

DO - 10.1038/ncb2877

M3 - Article

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VL - 15

SP - 1263

EP - 1265

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 11

ER -

Crosstalk between mTor Complexes

Abstract

ASJC Scopus subject areas

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