Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate

Beverly R. Vincent; David J. Clarke; Douglas R. Smyth; Dick De Vos; Edward R.T. Tiekink

doi:10.1155/MBD.2001.79

Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate

Beverly R. Vincent, David J. Clarke, Douglas R. Smyth, Dick De Vos, Edward R.T. Tiekink

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID₅₀ 250 - 2500 ng/ml).

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Metal-Based Drugs
Volume	8
Issue number	2
DOIs	https://doi.org/10.1155/MBD.2001.79
Publication status	Published or Issued - 2001
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology
Drug Discovery
Inorganic Chemistry

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10.1155/MBD.2001.79

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abstract = "The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 - 2500 ng/ml).",

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AU - Clarke, David J.

AU - Smyth, Douglas R.

AU - De Vos, Dick

AU - Tiekink, Edward R.T.

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AB - The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 - 2500 ng/ml).

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Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate

Abstract

ASJC Scopus subject areas

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