Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy∗Phine)2

Yong Yang, Yee Hwee Lim, Edward G. Robins, Charles W. Johannes

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15 Citations (Scopus)


The PdCl2(Cy∗Phine)2 precatalyst containing the meta-terarylphosphine ligand, Cy∗Phine, can effectively mediate decarboxylative cross-coupling with a diverse range of (hetero-)aryl, aryl and alkyl chlorides including those with unprotected functionality. Using a facile and robust protocol, this process was extended to the first synthesis of symmetrical di(heteroaryl)alkynes via tandem Sonogashira/decarboxylative cross-coupling of heteroaryl chlorides and propiolic acid.

Original languageEnglish
Pages (from-to)72810-72814
Number of pages5
JournalRSC Advances
Issue number76
Publication statusPublished or Issued - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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