Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

Ashlee Thomson; Jacqueline Rehn; David Yeung; James Breen; Deborah White

doi:10.1038/s41698-025-00887-9

Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

Ashlee Thomson, Jacqueline Rehn, David Yeung, James Breen, Deborah White

Research output: Contribution to journal › Review article › peer-review

Abstract

Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category. These fusions often result in enhancer hijacking, upregulation of partner proto-oncogenes and contribute to leukemogenesis. This review highlights the mechanisms underlying IGH gene fusions, the critical role they play in ALL pathogenesis, and current detection technologies.

Original language	English
Article number	99
Journal	npj Precision Oncology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41698-025-00887-9
Publication status	Published or Issued - Dec 2025

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/s41698-025-00887-9

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title = "Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia",

abstract = "Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category. These fusions often result in enhancer hijacking, upregulation of partner proto-oncogenes and contribute to leukemogenesis. This review highlights the mechanisms underlying IGH gene fusions, the critical role they play in ALL pathogenesis, and current detection technologies.",

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AB - Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category. These fusions often result in enhancer hijacking, upregulation of partner proto-oncogenes and contribute to leukemogenesis. This review highlights the mechanisms underlying IGH gene fusions, the critical role they play in ALL pathogenesis, and current detection technologies.

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Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

Abstract

ASJC Scopus subject areas

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