TY - JOUR
T1 - Diabetes
T2 - A 21st century challenge
AU - Zimmet, Paul Z.
AU - Magliano, Dianna J.
AU - Herman, William H.
AU - Shaw, Jonathan E.
N1 - Funding Information:
This Review was supported partly by the Victorian Government's OIS Program. JES is supported by a National Health and Medical Research Council fellowship ( 586623 ). WHH is supported by Grant Number P30DK092926 (MCDTR) from the National Institute of Diabetes and Digestive and Kidney Diseases . We thank David Whiting (NHS Medway, Rochester, UK), Leonor Guariguata (International Diabetes Federation, Brussels, Belgium), and the International Diabetes Federation for access to the latest global predictions data for diabetes, and to Assam El Osta (Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia), Mark Cooper (Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia), and Sir Peter Gluckman (Liggins Institute, University of Auckland, New Zealand) for their comments on the Review.
PY - 2014/1
Y1 - 2014/1
N2 - The number of people with diabetes worldwide has more than doubled during the past 20 years. One of the most worrying features of this rapid increase is the emergence of type 2 diabetes in children, adolescents, and young adults. Although the role of traditional risk factors for type 2 diabetes (eg, genetic, lifestyle, and behavioural risk factors) has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. Epidemiological data predict an inexorable and unsustainable increase in global health expenditure attributable to diabetes, so disease prevention should be given high priority. An integrated approach is needed to prevent type 2 diabetes, taking into account its many origins and heterogeneity. Thus, research needs to be directed at improved understanding of the potential role of determinants such as the maternal environment and other early life factors, as well as changing trends in global demography, to help shape disease prevention programmes.
AB - The number of people with diabetes worldwide has more than doubled during the past 20 years. One of the most worrying features of this rapid increase is the emergence of type 2 diabetes in children, adolescents, and young adults. Although the role of traditional risk factors for type 2 diabetes (eg, genetic, lifestyle, and behavioural risk factors) has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. Epidemiological data predict an inexorable and unsustainable increase in global health expenditure attributable to diabetes, so disease prevention should be given high priority. An integrated approach is needed to prevent type 2 diabetes, taking into account its many origins and heterogeneity. Thus, research needs to be directed at improved understanding of the potential role of determinants such as the maternal environment and other early life factors, as well as changing trends in global demography, to help shape disease prevention programmes.
UR - http://www.scopus.com/inward/record.url?scp=84890247834&partnerID=8YFLogxK
U2 - 10.1016/S2213-8587(13)70112-8
DO - 10.1016/S2213-8587(13)70112-8
M3 - Review article
C2 - 24622669
AN - SCOPUS:84890247834
SN - 2213-8587
VL - 2
SP - 56
EP - 64
JO - The Lancet Diabetes and Endocrinology
JF - The Lancet Diabetes and Endocrinology
IS - 1
ER -