Dietary interventions and tumor response to chemotherapy in breast cancer: A comprehensive review of preclinical and clinical data

Ifeoma J. Dikeocha, Hannah R. Wardill, Janet K. Coller, Joanne M. Bowen

Research output: Contribution to journalReview articlepeer-review

Abstract

Background & aims: Optimizing treatment efficacy is still a critical part in advancing the treatment of breast cancer. Dietary interventions have drawn significant attention for their potential to increase tumor sensitivity, with a plethora of strategies evaluated both preclinically and clinically. The aim of this paper is to explore these strategies, ranging from entire dietary programs to specific supplements, for their potential to directly enhance tumor sensitivity and chemotherapy adherence. Methods: PubMed, Scopus, Embase and Web of Science databases were searched up to September 2023. In this comprehensive review, preclinical and clinical research on dietary interventions used in conjunction with chemotherapy for breast cancer was examined and synthesized, to identify potential causal mechanisms. Results: 42 studies in total were identified and synthesized, 32 pre-clinical and 8 clinical studies. Conclusion: Although a topic of intense interest, the heterogeneity in approaches has resulted in a large but minimally impactful evidence base, further complicated by a limited understanding of the mechanisms at play. This review highlights the areas for further research to increase opportunities for nutritional-based interventions as adjuvant to chemotherapy for breast cancer.

Original languageEnglish
Pages (from-to)462-475
Number of pages14
JournalClinical Nutrition ESPEN
Volume63
DOIs
Publication statusPublished or Issued - Oct 2024

Keywords

  • Breast cancer
  • Chemotherapy
  • Diet
  • Tumor response

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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