Dismantling the bacterial virulence program

Morgan A. Alford, Daniel Pletzer, Robert E.W. Hancock

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


In the face of rising antimicrobial resistance, there is an urgent need for the development of efficient and effective anti-infective compounds. Adaptive resistance, a reversible bacterial phenotype characterized by the ability to surmount antibiotic challenge without mutation, is triggered to cope in situ with several stressors and is very common clinically. Thus, it is important to target stress-response effectors that contribute to in vivo adaptations and associated lifestyles such as biofilm formation. Interfering with these proteins should provide a means of dismantling bacterial virulence for treating infectious diseases, in combination with conventional antibiotics.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalMicrobial Biotechnology
Issue number3
Publication statusPublished or Issued - May 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology

Cite this