Does gut microbiota affect atrial rhythm? Causalities and speculations

Dominik Linz, Monika Gawałko, Prashanthan Sanders, John Penders, Na Li, Stanley Nattel, Dobromir Dobrev

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Dietary intake has been shown to change the composition of gut microbiota and some changes in microbiota (dysbiosis) have been linked to diabetes, hypertension, and obesity, which are established risk factors for atrial fibrillation (AF). In addition, intestinal dysbiosis generates microbiota-derived bioactive metabolites that might exert proarrhythmic actions. Although emerging preclinical investigations and clinical observational cohort studies suggest a possible role of gut dysbiosis in AF promotion, the exact mechanisms through which dysbiosis contributes to AF remain unclear. This Viewpoint article briefly reviews evidence suggesting that abnormalities in the intestinal microbiota play an important and little-recognized role in the pathophysiology of AF and that an improved understanding of this role may open up new possibilities in the management of AF.

Original languageEnglish
Pages (from-to)3521-3525
Number of pages5
JournalEuropean heart journal
Volume42
Issue number35
DOIs
Publication statusPublished or Issued - 14 Sept 2021
Externally publishedYes

Keywords

  • Arrhythmia
  • Atrial fibrillation
  • cardiometabolic
  • dysbiosis
  • gut microbiota
  • metabolites

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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