Does ovarian hyperstimulation in intrauterine insemination for cervical factor subfertility improve pregnancy rates?

Pieternel Steures, Jan Willem van der Steeg, Harold R. Verhoeve, Peter A. van Dop, Peter G.A. Hompes, Patrick M.M. Bossuyt, Fulco van der Veen, J. Dik F. Habbema, Marinus J.C. Eijkemans, Ben W.J. Mol

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Background: Intrauterine insemination (IUI) can be performed with or without controlled ovarian hyperstimulation (COH). Studies in which the additional benefit of COH on IUI for cervical factor subfertility is assessed are lacking. We assessed whether COH in IUI improved pregnancy rates in cervical factor subfertility. Methods: We performed a historical cohort study among couples with cervical factor subfertility, treated with IUI. A cervical factor was diagnosed by a well-timed, non-progressive post-coital test with normal semen parameters. We compared ongoing pregnancy rate per cycle in groups treated with IUI with or without COH. We tabulated ongoing pregnancy rates per cycle number and compared the effectiveness of COH by stratified univariable analysis. Results: We included 181 couples who underwent 330 cycles without COH and 417 cycles with COH. Ongoing pregnancy rates in IUI cycles without and with COH were 9.7% and 12.7%, respectively (odds ratio 1.4; 95% confidence interval 0.85-2.2). The pregnancy rates in IUI without COH in cycles 1, 2, 3 and 4 were 14%, 11%, 6% and 15%, respectively. For IUI with COH, these rates were 17%, 15%, 14% and 16%, respectively. Conclusions: Although our data indicate that COH improves the pregnancy rate over IUI without COH, IUI without COH generates acceptable pregnancy rates in couples with cervical factor subfertility. Since IUI without COH bears no increased risk for multiple pregnancy, this treatment should be seriously considered in couples with cervical factor subfertility.

Original languageEnglish
Pages (from-to)2263-2266
Number of pages4
JournalHuman Reproduction
Issue number10
Publication statusPublished or Issued - Oct 2004
Externally publishedYes


  • Cervical factor
  • Controlled ovarian hyperstimulation
  • Intrauterine insemination
  • Ongoing pregnancy
  • Subfertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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