Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the rat

Kim M. Hemsley; Eleanor J. Farrall; Ann D. Crocker

doi:10.1016/S0304-3940(01)02460-0

Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the rat

Kim M. Hemsley, Eleanor J. Farrall, Ann D. Crocker

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The effects of injecting an irreversible dopamine receptor antagonist, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) bilaterally into the subthalamic nucleus (STN) on changes in muscle tone and behaviour were investigated. Increased muscle tone (i.e. rigidity) was assessed quantitatively as increases in tonic electromyographic (EMG) activity in the hindlimb muscles of conscious, unrestrained rats. Significant, sustained increases in EMG activity were observed for 3-5 h post-injection in the tibialis and gastrocnemius muscles following injection of EEDQ into the STN. This effect was associated with 73% dopamine D1 and 66% dopamine D2 receptor occupancy in the STN, while dopamine receptors in surrounding regions were minimally occupied. These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Neuroscience Letters
Volume	317
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(01)02460-0
Publication status	Published or Issued - 14 Jan 2002

Keywords

Basal ganglia
Dopamine receptors
Muscle tone
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Rat
Subthalamic nucleus

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(01)02460-0

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title = "Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the rat",

abstract = "The effects of injecting an irreversible dopamine receptor antagonist, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) bilaterally into the subthalamic nucleus (STN) on changes in muscle tone and behaviour were investigated. Increased muscle tone (i.e. rigidity) was assessed quantitatively as increases in tonic electromyographic (EMG) activity in the hindlimb muscles of conscious, unrestrained rats. Significant, sustained increases in EMG activity were observed for 3-5 h post-injection in the tibialis and gastrocnemius muscles following injection of EEDQ into the STN. This effect was associated with 73% dopamine D1 and 66% dopamine D2 receptor occupancy in the STN, while dopamine receptors in surrounding regions were minimally occupied. These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone.",

keywords = "Basal ganglia, Dopamine receptors, Muscle tone, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, Rat, Subthalamic nucleus",

author = "Hemsley, {Kim M.} and Farrall, {Eleanor J.} and Crocker, {Ann D.}",

note = "Funding Information: The authors wish to thank Eleanor Farrall for her valuable contribution in the initial phase of this study. The authors gratefully acknowledge the financial support of the National Health and Medical Research Council (NHMRC) of Australia.",

year = "2002",

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doi = "10.1016/S0304-3940(01)02460-0",

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AU - Hemsley, Kim M.

AU - Farrall, Eleanor J.

AU - Crocker, Ann D.

N1 - Funding Information: The authors wish to thank Eleanor Farrall for her valuable contribution in the initial phase of this study. The authors gratefully acknowledge the financial support of the National Health and Medical Research Council (NHMRC) of Australia.

PY - 2002/1/14

Y1 - 2002/1/14

N2 - The effects of injecting an irreversible dopamine receptor antagonist, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) bilaterally into the subthalamic nucleus (STN) on changes in muscle tone and behaviour were investigated. Increased muscle tone (i.e. rigidity) was assessed quantitatively as increases in tonic electromyographic (EMG) activity in the hindlimb muscles of conscious, unrestrained rats. Significant, sustained increases in EMG activity were observed for 3-5 h post-injection in the tibialis and gastrocnemius muscles following injection of EEDQ into the STN. This effect was associated with 73% dopamine D1 and 66% dopamine D2 receptor occupancy in the STN, while dopamine receptors in surrounding regions were minimally occupied. These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone.

AB - The effects of injecting an irreversible dopamine receptor antagonist, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) bilaterally into the subthalamic nucleus (STN) on changes in muscle tone and behaviour were investigated. Increased muscle tone (i.e. rigidity) was assessed quantitatively as increases in tonic electromyographic (EMG) activity in the hindlimb muscles of conscious, unrestrained rats. Significant, sustained increases in EMG activity were observed for 3-5 h post-injection in the tibialis and gastrocnemius muscles following injection of EEDQ into the STN. This effect was associated with 73% dopamine D1 and 66% dopamine D2 receptor occupancy in the STN, while dopamine receptors in surrounding regions were minimally occupied. These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone.

KW - Basal ganglia

KW - Dopamine receptors

KW - Muscle tone

KW - N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

KW - Rat

KW - Subthalamic nucleus

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U2 - 10.1016/S0304-3940(01)02460-0

DO - 10.1016/S0304-3940(01)02460-0

M3 - Article

C2 - 11755255

AN - SCOPUS:0037074112

VL - 317

SP - 123

EP - 126

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -

Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the rat

Abstract

Keywords

ASJC Scopus subject areas

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