TY - JOUR
T1 - Effect of 12 month oral testosterone on testosterone deficiency symptoms in symptomatic elderly males with low-normal gonadal status
AU - Haren, Matthew
AU - Chapman, Ian
AU - Coates, Penelope
AU - Morley, John
AU - Wittert, Gary
N1 - Funding Information:
This study was sponsored by Organon Pty Ltd and the University of Adelaide. Organon Pty Ltd was involved in the study design.
PY - 2005/3
Y1 - 2005/3
N2 - Background: Relative androgen deficiency in ageing males is assumed to have adverse health effects. This study assessed the effect of 12 months' standard dose, oral testosterone, on symptoms attributed to testosterone deficiency in older men with plasma testosterone levels in the low-normal range for young men. Methods: Testosterone undecanoate (TU, 80 mg bid) or placebo was administered for one year to 76 healthy men, 60 years or older, with a free testosterone index (FTI) of 0.3-0.5 and significant symptoms on a questionnaire designed to evaluate androgen deficiency (ADAM). The ADAM was completed at baseline, 6 and 12 months. Hormone and safety data were collected at baseline, 1, 3, 6 and 12 months. Results: After 12 months, plasma total testosterone was unchanged in both groups and sex hormone binding globulin decreased in the testosterone group (P=0.01). FTI and calculated bioavailable testosterone (cBT) were greater in the testosterone group as compared with the placebo group (P=0.021 and 0.025, respectively). There was no significant difference in total symptom score between testosterone and placebo groups after 12 months of oral TU. However, there were trends toward improvements in sadness/grumpiness (P=0.063), reduced erection strength (P=0.059) and decreased work performance symptoms (P=0.077), particularly in men with baseline cBT levels below 3.1 nmol/l. Conclusions: This study concludes that 80 mg bid oral TU does not improve overall ADAM questionnaire scores in older men with low-normal gonadal status. Oral TU may preserve mood and erectile function, as assessed by this questionnaire, particularly in men with the lowest testosterone levels.
AB - Background: Relative androgen deficiency in ageing males is assumed to have adverse health effects. This study assessed the effect of 12 months' standard dose, oral testosterone, on symptoms attributed to testosterone deficiency in older men with plasma testosterone levels in the low-normal range for young men. Methods: Testosterone undecanoate (TU, 80 mg bid) or placebo was administered for one year to 76 healthy men, 60 years or older, with a free testosterone index (FTI) of 0.3-0.5 and significant symptoms on a questionnaire designed to evaluate androgen deficiency (ADAM). The ADAM was completed at baseline, 6 and 12 months. Hormone and safety data were collected at baseline, 1, 3, 6 and 12 months. Results: After 12 months, plasma total testosterone was unchanged in both groups and sex hormone binding globulin decreased in the testosterone group (P=0.01). FTI and calculated bioavailable testosterone (cBT) were greater in the testosterone group as compared with the placebo group (P=0.021 and 0.025, respectively). There was no significant difference in total symptom score between testosterone and placebo groups after 12 months of oral TU. However, there were trends toward improvements in sadness/grumpiness (P=0.063), reduced erection strength (P=0.059) and decreased work performance symptoms (P=0.077), particularly in men with baseline cBT levels below 3.1 nmol/l. Conclusions: This study concludes that 80 mg bid oral TU does not improve overall ADAM questionnaire scores in older men with low-normal gonadal status. Oral TU may preserve mood and erectile function, as assessed by this questionnaire, particularly in men with the lowest testosterone levels.
KW - Ageing
KW - Androgen deficiency
KW - Elderly
KW - Men
KW - Randomised controlled trial
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=14744283305&partnerID=8YFLogxK
U2 - 10.1093/ageing/afi003
DO - 10.1093/ageing/afi003
M3 - Article
C2 - 15596419
AN - SCOPUS:14744283305
SN - 0002-0729
VL - 34
SP - 125
EP - 130
JO - Age and Ageing
JF - Age and Ageing
IS - 2
ER -