TY - JOUR
T1 - Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
AU - Larson-Meyer, D. Enette
AU - Newcomer, Bradley R.
AU - Heilbronn, Leonie
AU - Volaufova, Julia
AU - Smith, Steven R.
AU - Alfonso, Anthony J.
AU - Lefevre, Michael
AU - Rood, Jennifer C.
AU - Williamson, Donald A.
AU - Ravussin, Eric
AU - DeLany, James
AU - De Jonge, Lilian
AU - Nguyen, Tuong
AU - Martin, Corby K.
AU - Most, Marlene M.
AU - Greenway, Frank L.
AU - York-Crow, Emily
AU - Anton, Steven
AU - Champagne, Catherine
AU - Dahmer, Brenda
AU - Deutsch, Andy
AU - Geiselman, Paula
AU - Howard, Jennifer
AU - Ihrig, Jana
AU - Marquis, Darlene
AU - Murla, Connie
AU - Owens, Sean
AU - Stewart, Aimee
AU - Tarver, Vanessa
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/6
Y1 - 2008/6
N2 - Objective: Nonalcoholic fatty liver disease (NAFLD) and its association with insulin resistance are increasingly recognized as major health burdens. The main objectives of this study were to assess the relation between liver lipid content and serum lipids, markers of liver function and inflammation in healthy overweight subjects, and to determine whether caloric restriction (CR) (which improves insulin resistance) reduces liver lipids in association with these same measures. Methods and Procedures: Forty-six white and black overweight men and women (BMI = 24.7-31.3 kg/m2) were randomized to "control (CO)" = 100% energy requirements; "CR" = 25%; "caloric restriction and increased structured exercise (CR+EX)"= 12.5% CR + 12.5% increase in energy expenditure through exercise; or "low-calorie diet (LCD)" = 15% weight loss by liquid diet followed by weight-maintenance, for 6 months. Liver lipid content was assessed by magnetic resonance spectroscopy (MRS) and computed tomography (CT). Lipid concentrations, markers of liver function (alanine aminotransferase (ALT), alkaline phosphatase (ALK)), and whole-body inflammation (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)) were measured in fasting blood. Results: At baseline, increased liver lipid content (by MRS) correlated (P < 0.05) with elevated fasting triglyceride (r = 0.52), ALT (r = 0.42), and hsCRP (r = 0.33) concentrations after adjusting for sex, race, and alcohol consumption. With CR, liver lipid content was significantly lowered by CR, CR+EX, and LCD (detected by MRS only). The reduction in liver lipid content, however, was not significantly correlated with the reduction in triglycerides (r = 0.26; P = 0.11) or with the changes in ALT, high-density lipoprotein (HDL)-cholesterol, or markers of whole-body inflammation. Discussion: CR may be beneficial for reducing liver lipid and lowering triglycerides in overweight subjects without known NAFLD.
AB - Objective: Nonalcoholic fatty liver disease (NAFLD) and its association with insulin resistance are increasingly recognized as major health burdens. The main objectives of this study were to assess the relation between liver lipid content and serum lipids, markers of liver function and inflammation in healthy overweight subjects, and to determine whether caloric restriction (CR) (which improves insulin resistance) reduces liver lipids in association with these same measures. Methods and Procedures: Forty-six white and black overweight men and women (BMI = 24.7-31.3 kg/m2) were randomized to "control (CO)" = 100% energy requirements; "CR" = 25%; "caloric restriction and increased structured exercise (CR+EX)"= 12.5% CR + 12.5% increase in energy expenditure through exercise; or "low-calorie diet (LCD)" = 15% weight loss by liquid diet followed by weight-maintenance, for 6 months. Liver lipid content was assessed by magnetic resonance spectroscopy (MRS) and computed tomography (CT). Lipid concentrations, markers of liver function (alanine aminotransferase (ALT), alkaline phosphatase (ALK)), and whole-body inflammation (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP)) were measured in fasting blood. Results: At baseline, increased liver lipid content (by MRS) correlated (P < 0.05) with elevated fasting triglyceride (r = 0.52), ALT (r = 0.42), and hsCRP (r = 0.33) concentrations after adjusting for sex, race, and alcohol consumption. With CR, liver lipid content was significantly lowered by CR, CR+EX, and LCD (detected by MRS only). The reduction in liver lipid content, however, was not significantly correlated with the reduction in triglycerides (r = 0.26; P = 0.11) or with the changes in ALT, high-density lipoprotein (HDL)-cholesterol, or markers of whole-body inflammation. Discussion: CR may be beneficial for reducing liver lipid and lowering triglycerides in overweight subjects without known NAFLD.
UR - http://www.scopus.com/inward/record.url?scp=44449171470&partnerID=8YFLogxK
U2 - 10.1038/oby.2008.201
DO - 10.1038/oby.2008.201
M3 - Article
C2 - 18421281
AN - SCOPUS:44449171470
VL - 16
SP - 1355
EP - 1362
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 6
ER -