Effect of folic acid supplementation on plasma zinc concentrations of young women

Timothy J. Green; C. Murray Skeaff; Susan J. Whiting; Rosalind S. Gibson

doi:10.1016/S0899-9007(02)01100-0

Effect of folic acid supplementation on plasma zinc concentrations of young women

Timothy J. Green, C. Murray Skeaff, Susan J. Whiting, Rosalind S. Gibson

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

Original language	English
Pages (from-to)	522-523
Number of pages	2
Journal	Nutrition
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/S0899-9007(02)01100-0
Publication status	Published or Issued - 1 Jun 2003
Externally published	Yes

Keywords

Folic acid
Plasma zinc
Red cell folate
Supplements
Women
Zinc

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Access to Document

10.1016/S0899-9007(02)01100-0

Cite this

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title = "Effect of folic acid supplementation on plasma zinc concentrations of young women",

abstract = "OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.",

keywords = "Folic acid, Plasma zinc, Red cell folate, Supplements, Women, Zinc",

author = "Green, {Timothy J.} and Skeaff, {C. Murray} and Whiting, {Susan J.} and Gibson, {Rosalind S.}",

note = "Funding Information: This study was supported by the Otago Medical Research Foundation (Laurenson Award). Healtheries, New Zealand, provided supplements. ",

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doi = "10.1016/S0899-9007(02)01100-0",

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volume = "19",

pages = "522--523",

journal = "Nutrition",

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publisher = "Elsevier Inc.",

number = "6",

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TY - JOUR

T1 - Effect of folic acid supplementation on plasma zinc concentrations of young women

AU - Green, Timothy J.

AU - Skeaff, C. Murray

AU - Whiting, Susan J.

AU - Gibson, Rosalind S.

N1 - Funding Information: This study was supported by the Otago Medical Research Foundation (Laurenson Award). Healtheries, New Zealand, provided supplements.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

AB - OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

KW - Folic acid

KW - Plasma zinc

KW - Red cell folate

KW - Supplements

KW - Women

KW - Zinc

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U2 - 10.1016/S0899-9007(02)01100-0

DO - 10.1016/S0899-9007(02)01100-0

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C2 - 12781852

AN - SCOPUS:0038777168

SN - 0899-9007

VL - 19

SP - 522

EP - 523

JO - Nutrition

JF - Nutrition

IS - 6

ER -

Effect of folic acid supplementation on plasma zinc concentrations of young women

Abstract

Keywords

ASJC Scopus subject areas

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