TY - JOUR
T1 - Effects of a fish oil rich diet on hyperoxic lung damage in mice
AU - Jamieson, D.
AU - Lin, Y.
AU - Gibson, R.
N1 - Funding Information:
This work was supportedb y a grant from the Australian Research Council.
PY - 1993/12
Y1 - 1993/12
N2 - Mice were fed a chow diet plus 10% cellulose, 10% fish oil or 10% sunflower oil for 3 weeks, then exposed to 100% oxygen for 75 h. Large changes in lung fatty acid composition occurred, but this did not affect hyperoxic lung damage nor levels of thiobarbituric acid reactive substances or myeloperoxidase in lungs of mice following exposure to hyperoxia. Thus there is no evidence that the ingestion of large quantities of fish oil increased the susceptibility to the oxidative stress induced by hyperoxia.
AB - Mice were fed a chow diet plus 10% cellulose, 10% fish oil or 10% sunflower oil for 3 weeks, then exposed to 100% oxygen for 75 h. Large changes in lung fatty acid composition occurred, but this did not affect hyperoxic lung damage nor levels of thiobarbituric acid reactive substances or myeloperoxidase in lungs of mice following exposure to hyperoxia. Thus there is no evidence that the ingestion of large quantities of fish oil increased the susceptibility to the oxidative stress induced by hyperoxia.
UR - http://www.scopus.com/inward/record.url?scp=0027733759&partnerID=8YFLogxK
U2 - 10.1016/0952-3278(93)90184-X
DO - 10.1016/0952-3278(93)90184-X
M3 - Article
C2 - 8140126
AN - SCOPUS:0027733759
SN - 0952-3278
VL - 49
SP - 969
EP - 972
JO - Prostaglandins, Leukotrienes and Essential Fatty Acids
JF - Prostaglandins, Leukotrienes and Essential Fatty Acids
IS - 6
ER -