Efficacy and safety of oral immunotherapy for peanut, cow's milk, and hen's egg allergy: A systematic review of randomized controlled trials

Background: Oral immunotherapy (OIT) is a promising treatment for food allergies; however, safety is a concern. We synthesized evidence from the best randomized controlled trials (RCTs) on efficacy/safety of OIT for desensitization (DS) and remission (sustained unresponsiveness (SU)) in IgE mediated allergy to peanut, hen's eggs, and cow's milk. Body: We searched Pubmed, EMBASE, and Cochrane databases (Until Oct 22) identifying 16 eligible RCTs published in English measuring food allergy by food challenge at the beginning and at the end of the study. The Cochrane Risk of Bias tool was used to assess study quality. We found 18 eligible studies. There was evidence of efficacy for DS for all allergens: peanut (RR 11.32; 95% CI 5.93, 21.60, I² 49%, 8 studies); hen's egg (RR 4.67; 2.66, 8.21, I² 0%, 5 studies); cow's milk (RR 13.98; 3.51, 55.65, I² 0%, 4 studies) and evidence for SU for peanut (RR 7.74; 2.90, 20.69, I² 0%, 3 studies) and hen's egg (RR 6.91; 1.67, 28.57, I² 0%, 2 studies). Allergic events were increased with intervention, and risk of adrenaline use increased for peanut RR 2.96; 1.63, 5.35, I² 0%, 8 studies; egg RR 1.71; 0.42, 6.92, I² 0%, 6 studies; and milk RR 8.45; 2.02, 35.27, I² 0%, 4 studies. Conclusion: We found strong evidence that peanut, hen's egg, and cow's milk OIT can induce DS and some evidence for remission. There was a high risk of allergic reactions. Generalizability to the entire food allergic population is not known.