EIF2B: Recent structural and functional insights into a key regulator of translation

Noel C. Wortham; Christopher G. Proud

doi:10.1042/BST20150164

EIF2B: Recent structural and functional insights into a key regulator of translation

Noel C. Wortham, Christopher G. Proud

Nutrition, Diabetes And Gut Health

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed α through ε in order of increasing size. eIF2B is subject to tight regulation in the cell and may also serve additional functions. Here we review recent insights into the subunit organization of the mammalian eIF2B complex, gained both from structural studies of the complex and from studies of mutations of eIF2B that result in the neurological disorder leukoencephalopathy with vanishing white matter (VWM). We will also discuss recent data from yeast demonstrating a novel function of the eIF2B complex key for translational regulation.

Original language	English
Pages (from-to)	1234-1240
Number of pages	7
Journal	Biochemical Society Transactions
Volume	43
DOIs	https://doi.org/10.1042/BST20150164
Publication status	Published or Issued - 1 Dec 2015

Keywords

Eukaryotic initiation factor 2B (eIF2B)
Integrated stress response
Integrated stress response inhibitor (ISRIB)
Protein synthesis
Vanishing white matter

ASJC Scopus subject areas

Biochemistry

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10.1042/BST20150164

Cite this

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abstract = "The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed α through ε in order of increasing size. eIF2B is subject to tight regulation in the cell and may also serve additional functions. Here we review recent insights into the subunit organization of the mammalian eIF2B complex, gained both from structural studies of the complex and from studies of mutations of eIF2B that result in the neurological disorder leukoencephalopathy with vanishing white matter (VWM). We will also discuss recent data from yeast demonstrating a novel function of the eIF2B complex key for translational regulation.",

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EIF2B: Recent structural and functional insights into a key regulator of translation

Abstract

Keywords

ASJC Scopus subject areas

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