TY - JOUR
T1 - EIF2B
T2 - Recent structural and functional insights into a key regulator of translation
AU - Wortham, Noel C.
AU - Proud, Christopher G.
N1 - Publisher Copyright:
© 2015 Authors; published by Portland Press Limited.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed α through ε in order of increasing size. eIF2B is subject to tight regulation in the cell and may also serve additional functions. Here we review recent insights into the subunit organization of the mammalian eIF2B complex, gained both from structural studies of the complex and from studies of mutations of eIF2B that result in the neurological disorder leukoencephalopathy with vanishing white matter (VWM). We will also discuss recent data from yeast demonstrating a novel function of the eIF2B complex key for translational regulation.
AB - The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed α through ε in order of increasing size. eIF2B is subject to tight regulation in the cell and may also serve additional functions. Here we review recent insights into the subunit organization of the mammalian eIF2B complex, gained both from structural studies of the complex and from studies of mutations of eIF2B that result in the neurological disorder leukoencephalopathy with vanishing white matter (VWM). We will also discuss recent data from yeast demonstrating a novel function of the eIF2B complex key for translational regulation.
KW - Eukaryotic initiation factor 2B (eIF2B)
KW - Integrated stress response
KW - Integrated stress response inhibitor (ISRIB)
KW - Protein synthesis
KW - Vanishing white matter
UR - http://www.scopus.com/inward/record.url?scp=84969377017&partnerID=8YFLogxK
U2 - 10.1042/BST20150164
DO - 10.1042/BST20150164
M3 - Article
C2 - 26614666
AN - SCOPUS:84969377017
VL - 43
SP - 1234
EP - 1240
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
ER -