Environmental and genetic determinants of vitamin D status among older adults in London, UK

David A. Jolliffe; Yasmeen Hanifa; Karolina D. Witt; Timothy R. Venton; Marion Rowe; Peter M. Timms; Elina Hyppönen; Robert T. Walton; Christopher J. Griffiths; Adrian R. Martineau

doi:10.1016/j.jsbmb.2016.01.005

Environmental and genetic determinants of vitamin D status among older adults in London, UK

David A. Jolliffe, Yasmeen Hanifa, Karolina D. Witt, Timothy R. Venton, Marion Rowe, Peter M. Timms, Elina Hyppönen, Robert T. Walton, Christopher J. Griffiths, Adrian R. Martineau

Australian Centre For Precision Health

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Despite the high prevalence of vitamin D deficiency among older adults in the UK, studies investigating the determinants of vitamin D status in this group are lacking. We conducted a cross-sectional study in 222 older adults living in sheltered accommodation in London, UK, who were screened for participation in a clinical trial of vitamin D supplementation for the prevention of acute respiratory infection. Details of potential demographic and lifestyle determinants of vitamin D status were collected by questionnaire and blood samples were taken for analysis of serum 25-hydroxyvitamin D (25[OH]D) concentration and DNA extraction. Fifteen single nucleotide polymorphisms (SNP) in 6 genes (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR) previously reported to associate with circulating 25(OH)D concentration were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration. Mean serum 25(OH)D concentration was 42.7 nmol/L (SD 22.0); 144/222 (64.9%) participants had serum 25(OH)D concentrations <50 nmol/L. The following factors were independently associated with lower serum 25(OH)D concentration: non-white ethnicity (−8.6 nmol/L, 95% CI −14.9 to −2.3, P = 0.008); lack of vitamin D supplement consumption (−17.1 nmol/L, 95% CI −23.3 to −10.9, P < 0.001) vs. taking a daily supplement; sampling in Q1/January–March (−12.2 nmol/L, 95% CI −21.5 to −2.9, P = 0.01), and sampling in Q4/October–December (−10.3 nmol/L, 95% CI −20.2 to −0.4, P = 0.04) vs. sampling in Q3/July–September. None of the 15 SNP investigated independently associated with serum 25(OH)D concentration after correcting for multiple comparisons. In conclusion, vitamin D deficiency was highly prevalent among the older adults in this study; non-White ethnicity, lack of vitamin D supplement consumption and sampling in winter and spring independently associated with lower vitamin D status.

Original language	English
Pages (from-to)	30-35
Number of pages	6
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	164
DOIs	https://doi.org/10.1016/j.jsbmb.2016.01.005
Publication status	Published or Issued - 1 Nov 2016

Keywords

Ageing
Diet
Polymorphism
Season
Single nucleotide
Vitamin D

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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10.1016/j.jsbmb.2016.01.005

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@article{67e07137072d44c1b69892a3516e0dbd,

title = "Environmental and genetic determinants of vitamin D status among older adults in London, UK",

abstract = "Despite the high prevalence of vitamin D deficiency among older adults in the UK, studies investigating the determinants of vitamin D status in this group are lacking. We conducted a cross-sectional study in 222 older adults living in sheltered accommodation in London, UK, who were screened for participation in a clinical trial of vitamin D supplementation for the prevention of acute respiratory infection. Details of potential demographic and lifestyle determinants of vitamin D status were collected by questionnaire and blood samples were taken for analysis of serum 25-hydroxyvitamin D (25[OH]D) concentration and DNA extraction. Fifteen single nucleotide polymorphisms (SNP) in 6 genes (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR) previously reported to associate with circulating 25(OH)D concentration were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration. Mean serum 25(OH)D concentration was 42.7 nmol/L (SD 22.0); 144/222 (64.9%) participants had serum 25(OH)D concentrations <50 nmol/L. The following factors were independently associated with lower serum 25(OH)D concentration: non-white ethnicity (−8.6 nmol/L, 95% CI −14.9 to −2.3, P = 0.008); lack of vitamin D supplement consumption (−17.1 nmol/L, 95% CI −23.3 to −10.9, P < 0.001) vs. taking a daily supplement; sampling in Q1/January–March (−12.2 nmol/L, 95% CI −21.5 to −2.9, P = 0.01), and sampling in Q4/October–December (−10.3 nmol/L, 95% CI −20.2 to −0.4, P = 0.04) vs. sampling in Q3/July–September. None of the 15 SNP investigated independently associated with serum 25(OH)D concentration after correcting for multiple comparisons. In conclusion, vitamin D deficiency was highly prevalent among the older adults in this study; non-White ethnicity, lack of vitamin D supplement consumption and sampling in winter and spring independently associated with lower vitamin D status.",

keywords = "Ageing, Diet, Polymorphism, Season, Single nucleotide, Vitamin D",

author = "Jolliffe, {David A.} and Yasmeen Hanifa and Witt, {Karolina D.} and Venton, {Timothy R.} and Marion Rowe and Timms, {Peter M.} and Elina Hypp{\"o}nen and Walton, {Robert T.} and Griffiths, {Christopher J.} and Martineau, {Adrian R.}",

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doi = "10.1016/j.jsbmb.2016.01.005",

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AU - Jolliffe, David A.

AU - Hanifa, Yasmeen

AU - Witt, Karolina D.

AU - Venton, Timothy R.

AU - Rowe, Marion

AU - Timms, Peter M.

AU - Hyppönen, Elina

AU - Walton, Robert T.

AU - Griffiths, Christopher J.

AU - Martineau, Adrian R.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Despite the high prevalence of vitamin D deficiency among older adults in the UK, studies investigating the determinants of vitamin D status in this group are lacking. We conducted a cross-sectional study in 222 older adults living in sheltered accommodation in London, UK, who were screened for participation in a clinical trial of vitamin D supplementation for the prevention of acute respiratory infection. Details of potential demographic and lifestyle determinants of vitamin D status were collected by questionnaire and blood samples were taken for analysis of serum 25-hydroxyvitamin D (25[OH]D) concentration and DNA extraction. Fifteen single nucleotide polymorphisms (SNP) in 6 genes (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR) previously reported to associate with circulating 25(OH)D concentration were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration. Mean serum 25(OH)D concentration was 42.7 nmol/L (SD 22.0); 144/222 (64.9%) participants had serum 25(OH)D concentrations <50 nmol/L. The following factors were independently associated with lower serum 25(OH)D concentration: non-white ethnicity (−8.6 nmol/L, 95% CI −14.9 to −2.3, P = 0.008); lack of vitamin D supplement consumption (−17.1 nmol/L, 95% CI −23.3 to −10.9, P < 0.001) vs. taking a daily supplement; sampling in Q1/January–March (−12.2 nmol/L, 95% CI −21.5 to −2.9, P = 0.01), and sampling in Q4/October–December (−10.3 nmol/L, 95% CI −20.2 to −0.4, P = 0.04) vs. sampling in Q3/July–September. None of the 15 SNP investigated independently associated with serum 25(OH)D concentration after correcting for multiple comparisons. In conclusion, vitamin D deficiency was highly prevalent among the older adults in this study; non-White ethnicity, lack of vitamin D supplement consumption and sampling in winter and spring independently associated with lower vitamin D status.

AB - Despite the high prevalence of vitamin D deficiency among older adults in the UK, studies investigating the determinants of vitamin D status in this group are lacking. We conducted a cross-sectional study in 222 older adults living in sheltered accommodation in London, UK, who were screened for participation in a clinical trial of vitamin D supplementation for the prevention of acute respiratory infection. Details of potential demographic and lifestyle determinants of vitamin D status were collected by questionnaire and blood samples were taken for analysis of serum 25-hydroxyvitamin D (25[OH]D) concentration and DNA extraction. Fifteen single nucleotide polymorphisms (SNP) in 6 genes (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR) previously reported to associate with circulating 25(OH)D concentration were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration. Mean serum 25(OH)D concentration was 42.7 nmol/L (SD 22.0); 144/222 (64.9%) participants had serum 25(OH)D concentrations <50 nmol/L. The following factors were independently associated with lower serum 25(OH)D concentration: non-white ethnicity (−8.6 nmol/L, 95% CI −14.9 to −2.3, P = 0.008); lack of vitamin D supplement consumption (−17.1 nmol/L, 95% CI −23.3 to −10.9, P < 0.001) vs. taking a daily supplement; sampling in Q1/January–March (−12.2 nmol/L, 95% CI −21.5 to −2.9, P = 0.01), and sampling in Q4/October–December (−10.3 nmol/L, 95% CI −20.2 to −0.4, P = 0.04) vs. sampling in Q3/July–September. None of the 15 SNP investigated independently associated with serum 25(OH)D concentration after correcting for multiple comparisons. In conclusion, vitamin D deficiency was highly prevalent among the older adults in this study; non-White ethnicity, lack of vitamin D supplement consumption and sampling in winter and spring independently associated with lower vitamin D status.

KW - Ageing

KW - Diet

KW - Polymorphism

KW - Season

KW - Single nucleotide

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JO - Journal of Steroid Biochemistry and Molecular Biology

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ER -

Environmental and genetic determinants of vitamin D status among older adults in London, UK

Abstract

Keywords

ASJC Scopus subject areas

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