TY - JOUR
T1 - Epidermal growth factor receptor
T2 - Mechanisms of activation and signalling
AU - Jorissen, Robert N.
AU - Walker, Francesca
AU - Pouliot, Normand
AU - Garrett, Thomas P.J.
AU - Ward, Colin W.
AU - Burgess, Antony W.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/3/10
Y1 - 2003/3/10
N2 - The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-α, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
AB - The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-α, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
UR - http://www.scopus.com/inward/record.url?scp=0037429737&partnerID=8YFLogxK
U2 - 10.1016/S0014-4827(02)00098-8
DO - 10.1016/S0014-4827(02)00098-8
M3 - Review article
C2 - 12648464
AN - SCOPUS:0037429737
SN - 0014-4827
VL - 284
SP - 31
EP - 53
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -