ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

Ysabella Z.A. Van Sebille; Rachel J. Gibson; Hannah R. Wardill; Joanne M. Bowen

doi:10.1016/j.ctrv.2015.05.011

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill, Joanne M. Bowen

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Diarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapies. While the mechanisms of diarrhoea induced by traditional chemotherapy have been the focus of much research, the mechanism(s) of diarrhoea induced by small molecule ErbB TKI, have received relatively little attention. Given the increasing use of small molecule ErbB TKIs, identifying this mechanism is key to optimal cancer care. This paper critically reviews the literature and forms a hypothesis that diarrhoea induced by small molecule ErbB TKIs is driven by intestinal chloride secretion based on the negative regulation of chloride secretion by ErbB receptors being disrupted by tyrosine kinase inhibition.

Original language	English
Pages (from-to)	646-652
Number of pages	7
Journal	Cancer Treatment Reviews
Volume	41
Issue number	7
DOIs	https://doi.org/10.1016/j.ctrv.2015.05.011
Publication status	Published or Issued - 1 Jul 2015
Externally published	Yes

Keywords

Chloride secretion
Diarrhoea
ErbB (EGFR, HER)
Mucositis
TKI

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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10.1016/j.ctrv.2015.05.011

Cite this

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title = "ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis",

abstract = "Diarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapies. While the mechanisms of diarrhoea induced by traditional chemotherapy have been the focus of much research, the mechanism(s) of diarrhoea induced by small molecule ErbB TKI, have received relatively little attention. Given the increasing use of small molecule ErbB TKIs, identifying this mechanism is key to optimal cancer care. This paper critically reviews the literature and forms a hypothesis that diarrhoea induced by small molecule ErbB TKIs is driven by intestinal chloride secretion based on the negative regulation of chloride secretion by ErbB receptors being disrupted by tyrosine kinase inhibition.",

keywords = "Chloride secretion, Diarrhoea, ErbB (EGFR, HER), Mucositis, TKI",

author = "\{Van Sebille\}, \{Ysabella Z.A.\} and Gibson, \{Rachel J.\} and Wardill, \{Hannah R.\} and Bowen, \{Joanne M.\}",

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year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.ctrv.2015.05.011",

language = "English",

volume = "41",

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journal = "Cancer Treatment Reviews",

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TY - JOUR

T1 - ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea

T2 - Chloride secretion as a mechanistic hypothesis

AU - Van Sebille, Ysabella Z.A.

AU - Gibson, Rachel J.

AU - Wardill, Hannah R.

AU - Bowen, Joanne M.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Diarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapies. While the mechanisms of diarrhoea induced by traditional chemotherapy have been the focus of much research, the mechanism(s) of diarrhoea induced by small molecule ErbB TKI, have received relatively little attention. Given the increasing use of small molecule ErbB TKIs, identifying this mechanism is key to optimal cancer care. This paper critically reviews the literature and forms a hypothesis that diarrhoea induced by small molecule ErbB TKIs is driven by intestinal chloride secretion based on the negative regulation of chloride secretion by ErbB receptors being disrupted by tyrosine kinase inhibition.

AB - Diarrhoea is a common, debilitating and potentially life threatening toxicity of many cancer therapies. While the mechanisms of diarrhoea induced by traditional chemotherapy have been the focus of much research, the mechanism(s) of diarrhoea induced by small molecule ErbB TKI, have received relatively little attention. Given the increasing use of small molecule ErbB TKIs, identifying this mechanism is key to optimal cancer care. This paper critically reviews the literature and forms a hypothesis that diarrhoea induced by small molecule ErbB TKIs is driven by intestinal chloride secretion based on the negative regulation of chloride secretion by ErbB receptors being disrupted by tyrosine kinase inhibition.

KW - Chloride secretion

KW - Diarrhoea

KW - ErbB (EGFR, HER)

KW - Mucositis

KW - TKI

UR - https://www.scopus.com/pages/publications/84937633265

U2 - 10.1016/j.ctrv.2015.05.011

DO - 10.1016/j.ctrv.2015.05.011

M3 - Review article

C2 - 26073491

AN - SCOPUS:84937633265

SN - 0305-7372

VL - 41

SP - 646

EP - 652

JO - Cancer Treatment Reviews

JF - Cancer Treatment Reviews

IS - 7

ER -

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

Abstract

Keywords

ASJC Scopus subject areas

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