Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

Hassan Yousefnia, Samaneh Zolghadri, Saeed Shanehsazzadeh

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In this work, the absorbed dose of human organs for 177Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with 177Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both 177Lu-BPAMD and 177Lu-EDTMP is observed on the bone surface with 8.007 and 4.802mSv/MBq. Generally, 177Lu-BPAMD has considerable characteristics compared with 177Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalApplied Radiation and Isotopes
Volume104
DOIs
Publication statusPublished or Issued - 1 Oct 2015
Externally publishedYes

Keywords

  • Absorbed dose
  • BPAMD
  • EDTMP
  • Lu-177
  • RADAR

ASJC Scopus subject areas

  • Radiation

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