Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

Hassan Yousefnia; Samaneh Zolghadri; Saeed Shanehsazzadeh

doi:10.1016/j.apradiso.2015.06.033

Estimated human absorbed dose of ¹⁷⁷Lu-BPAMD based on mice data: Comparison with ¹⁷⁷Lu-EDTMP

Hassan Yousefnia, Samaneh Zolghadri, Saeed Shanehsazzadeh

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In this work, the absorbed dose of human organs for ¹⁷⁷Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with ¹⁷⁷Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both ¹⁷⁷Lu-BPAMD and ¹⁷⁷Lu-EDTMP is observed on the bone surface with 8.007 and 4.802mSv/MBq. Generally, ¹⁷⁷Lu-BPAMD has considerable characteristics compared with ¹⁷⁷Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

Original language	English
Pages (from-to)	128-135
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	104
DOIs	https://doi.org/10.1016/j.apradiso.2015.06.033 https://doi.org/10.1016/j.apradiso.2015.06.033
Publication status	Published or Issued - 1 Oct 2015
Externally published	Yes

Keywords

Absorbed dose
BPAMD
EDTMP
Lu-177
RADAR

ASJC Scopus subject areas

Radiation

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Cite this

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title = "Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP",

abstract = "In this work, the absorbed dose of human organs for 177Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with 177Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both 177Lu-BPAMD and 177Lu-EDTMP is observed on the bone surface with 8.007 and 4.802mSv/MBq. Generally, 177Lu-BPAMD has considerable characteristics compared with 177Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.",

keywords = "Absorbed dose, BPAMD, EDTMP, Lu-177, RADAR",

author = "Hassan Yousefnia and Samaneh Zolghadri and Saeed Shanehsazzadeh",

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language = "English",

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journal = "Applied Radiation and Isotopes",

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T1 - Estimated human absorbed dose of 177Lu-BPAMD based on mice data

T2 - Comparison with 177Lu-EDTMP

AU - Yousefnia, Hassan

AU - Zolghadri, Samaneh

AU - Shanehsazzadeh, Saeed

PY - 2015/10/1

Y1 - 2015/10/1

N2 - In this work, the absorbed dose of human organs for 177Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with 177Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both 177Lu-BPAMD and 177Lu-EDTMP is observed on the bone surface with 8.007 and 4.802mSv/MBq. Generally, 177Lu-BPAMD has considerable characteristics compared with 177Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

AB - In this work, the absorbed dose of human organs for 177Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with 177Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both 177Lu-BPAMD and 177Lu-EDTMP is observed on the bone surface with 8.007 and 4.802mSv/MBq. Generally, 177Lu-BPAMD has considerable characteristics compared with 177Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.

KW - Absorbed dose

KW - BPAMD

KW - EDTMP

KW - Lu-177

KW - RADAR

UR - https://www.scopus.com/pages/publications/84935441845

U2 - 10.1016/j.apradiso.2015.06.033

DO - 10.1016/j.apradiso.2015.06.033

M3 - Article

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SN - 0969-8043

VL - 104

SP - 128

EP - 135

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -