Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles

Justin W. Kenney, Claire E. Moore, Xuemin Wang, Christopher G. Proud

Research output: Contribution to journalReview articlepeer-review

134 Citations (Scopus)

Abstract

Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the elongation stage of protein synthesis, which normally consumes a great deal of energy and amino acids. The activity of eEF2K is normally dependent on calcium ions and calmodulin. eEF2K is also regulated by a plethora of other inputs, including inhibition by signalling downstream of anabolic signalling pathways such as the mammalian target of rapamycin complex 1. Recent data show that eEF2K helps to protect cancer cells against nutrient starvation and is also cytoprotective in other settings, including hypoxia. Growing evidence points to roles for eEF2K in neurological processes such as learning and memory and perhaps in depression.

Original languageEnglish
Pages (from-to)15-27
Number of pages13
JournalAdvances in Biological Regulation
Volume55
DOIs
Publication statusPublished or Issued - May 2014
Externally publishedYes

Keywords

  • Calmodulin
  • EEF2
  • MRNA translation
  • MTORC1
  • Protein synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Cancer Research

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