Evolving targets for lipid-modifying therapy

Rose Q. Do, Stephen J. Nicholls, Gregory G. Schwartz

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed. This review article summarizes existing and emerging therapeutic strategies to modify all types of lipoproteins, whose concentration and function are critical in the progression of atherosclerosis.

Original languageEnglish
Pages (from-to)1215-1230
Number of pages16
JournalEMBO Molecular Medicine
Issue number10
Publication statusPublished or Issued - 1 Oct 2014


  • Atherosclerosis
  • Cholesterol
  • Lipoproteins
  • Triglycerides

ASJC Scopus subject areas

  • Molecular Medicine

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