TY - JOUR
T1 - Findings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus
AU - Ng, Arnold C.T.
AU - Delgado, Victoria
AU - Bertini, Matteo
AU - van der Meer, Rutger W.
AU - Rijzewijk, Luuk J.
AU - Shanks, Miriam
AU - Nucifora, Gaetano
AU - Smit, Johannes W.A.
AU - Diamant, Michaela
AU - Romijn, Johannes A.
AU - de Roos, Albert
AU - Leung, Dominic Y.
AU - Lamb, Hildo J.
AU - Bax, Jeroen J.
N1 - Funding Information:
Dr. Bax received grants from Biotronik, Lake Oswego, Oregon; Medtronic, Minneapolis, Minnesota; Boston Scientific, Natick, Massachusetts; Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts; St. Jude Medical, St. Paul, Minnesota; GE Healthcare, and Edwards Lifesciences, Irvine, California.
PY - 2009/11/15
Y1 - 2009/11/15
N2 - Regional left ventricular (LV) myocardial functional changes in early diabetic cardiomyopathy have not been well documented. LV multidirectional strain and strain rate analyses by 2-dimensional speckle tracking were used to detect subtle myocardial dysfunction in 47 asymptomatic, male patients (age 57 ± 6 years) with type 2 diabetes mellitus. The results were compared to those from 53 male controls matched by age, body mass index, and body surface area. No differences were found in the LV end-diastolic volume index (40.7 ± 8.9 vs 44.1 ± 7.8 ml/m2, p = NS), end-systolic volume index (16.0 ± 4.8 vs 17.8 ± 4.3 ml/m2, p = NS), ejection fraction (61.0 ± 5.5% vs 59.8 ± 5.3%, p = NS). The transmitral E/A (0.95 ± 0.21 vs 1.12 ± 0.32, p = 0.007) and pulmonary S/D (1.45 ± 0.28 vs 1.25 ± 0.27, p = 0.001) ratios were more impaired in the patients with diabetes mellitus. Importantly, the diabetic patients had impaired longitudinal, but preserved circumferential and radial systolic and diastolic, function. Diabetes mellitus was an independent predictor for longitudinal strain, systolic strain rate and early diastolic strain rate on multiple linear regression analysis (all p <0.001). In conclusion, the LV longitudinal systolic and diastolic function were impaired, but the circumferential and radial functions were preserved in patients with uncomplicated type 2 diabetes mellitus.
AB - Regional left ventricular (LV) myocardial functional changes in early diabetic cardiomyopathy have not been well documented. LV multidirectional strain and strain rate analyses by 2-dimensional speckle tracking were used to detect subtle myocardial dysfunction in 47 asymptomatic, male patients (age 57 ± 6 years) with type 2 diabetes mellitus. The results were compared to those from 53 male controls matched by age, body mass index, and body surface area. No differences were found in the LV end-diastolic volume index (40.7 ± 8.9 vs 44.1 ± 7.8 ml/m2, p = NS), end-systolic volume index (16.0 ± 4.8 vs 17.8 ± 4.3 ml/m2, p = NS), ejection fraction (61.0 ± 5.5% vs 59.8 ± 5.3%, p = NS). The transmitral E/A (0.95 ± 0.21 vs 1.12 ± 0.32, p = 0.007) and pulmonary S/D (1.45 ± 0.28 vs 1.25 ± 0.27, p = 0.001) ratios were more impaired in the patients with diabetes mellitus. Importantly, the diabetic patients had impaired longitudinal, but preserved circumferential and radial systolic and diastolic, function. Diabetes mellitus was an independent predictor for longitudinal strain, systolic strain rate and early diastolic strain rate on multiple linear regression analysis (all p <0.001). In conclusion, the LV longitudinal systolic and diastolic function were impaired, but the circumferential and radial functions were preserved in patients with uncomplicated type 2 diabetes mellitus.
UR - http://www.scopus.com/inward/record.url?scp=71749121856&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2009.06.063
DO - 10.1016/j.amjcard.2009.06.063
M3 - Article
C2 - 19892057
AN - SCOPUS:71749121856
SN - 0002-9149
VL - 104
SP - 1398
EP - 1401
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -