FRAIL scale: Predictive validity and diagnostic test accuracy

Mark Q. Thompson; Olga Theou; Graeme R. Tucker; Robert J. Adams; Renuka Visvanathan

doi:10.1111/ajag.12829

FRAIL scale: Predictive validity and diagnostic test accuracy

Mark Q. Thompson, Olga Theou, Graeme R. Tucker, Robert J. Adams, Renuka Visvanathan

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

Original language	English
Pages (from-to)	e529-e536
Journal	Australasian Journal on Ageing
Volume	39
Issue number	4
DOIs	https://doi.org/10.1111/ajag.12829
Publication status	Published or Issued - Dec 2020
Externally published	Yes

Keywords

Australia
frailty
mortality
screening

ASJC Scopus subject areas

Community and Home Care
Geriatrics and Gerontology

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10.1111/ajag.12829

Cite this

@article{c1f1b0071ea24d298fc0a5ca2c27b9dc,

title = "FRAIL scale: Predictive validity and diagnostic test accuracy",

abstract = "Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8\% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8\%) and Youden index (0.50), but not sensitivity (63.6\%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.",

keywords = "Australia, frailty, mortality, screening",

author = "Thompson, \{Mark Q.\} and Olga Theou and Tucker, \{Graeme R.\} and Adams, \{Robert J.\} and Renuka Visvanathan",

note = "Publisher Copyright: {\textcopyright} 2020 AJA Inc.",

year = "2020",

month = dec,

doi = "10.1111/ajag.12829",

language = "English",

volume = "39",

pages = "e529--e536",

journal = "Australasian Journal on Ageing",

issn = "1440-6381",

publisher = "Wiley-Blackwell",

number = "4",

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TY - JOUR

T1 - FRAIL scale

T2 - Predictive validity and diagnostic test accuracy

AU - Thompson, Mark Q.

AU - Theou, Olga

AU - Tucker, Graeme R.

AU - Adams, Robert J.

AU - Visvanathan, Renuka

PY - 2020/12

Y1 - 2020/12

N2 - Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

AB - Objective: To examine the predictive validity of the FRAIL scale for mortality, and diagnostic test accuracy (DTA) against the frailty phenotype (FP). Measurement: Frailty was measured in 846 community-dwelling adults (mean age 74.3[SD 6.3] years, 54.8% female) using a modified FRAIL scale and modified FP. Mortality was matched to death records. Results: The FRAIL scale demonstrated significant predictive validity for mortality up to 10 years (Frail adjHR: 2.60, P <.001). DTA findings were acceptable for specificity (86.8%) and Youden index (0.50), but not sensitivity (63.6%), or area under the receiver operator curve (auROC) (0.75). DTA estimates were more acceptable when a cut-point of ≥2 characteristics was used rather than ≥3 in the primary DTA analysis. Conclusion: The FRAIL scale is a valid predictor of mortality. DTA estimates depend on FRAIL scale cut-point used. This instrument is a potentially useful frailty screening tool.

KW - Australia

KW - frailty

KW - mortality

KW - screening

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DO - 10.1111/ajag.12829

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SN - 1440-6381

VL - 39

SP - e529-e536

JO - Australasian Journal on Ageing

JF - Australasian Journal on Ageing

IS - 4

ER -

FRAIL scale: Predictive validity and diagnostic test accuracy

Abstract

Keywords

ASJC Scopus subject areas

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