Abstract
Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.
Original language | English |
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Article number | 5437 |
Journal | Scientific reports |
Volume | 4 |
DOIs | |
Publication status | Published or Issued - 25 Jun 2014 |
ASJC Scopus subject areas
- General