Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers, J. Kozlowska, J. Keeble, K. Metcalfe, M. Fao, S. E. Dowd, A. J. Mason, M. A. McGuckin, K. D. Bruce

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

Original languageEnglish
Article number5437
JournalScientific reports
Publication statusPublished or Issued - 25 Jun 2014

ASJC Scopus subject areas

  • General

Cite this