Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers; J. Kozlowska; J. Keeble; K. Metcalfe; M. Fao; S. E. Dowd; A. J. Mason; M. A. McGuckin; K. D. Bruce

doi:10.1038/srep05437

Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

G. B. Rogers, J. Kozlowska, J. Keeble, K. Metcalfe, M. Fao, S. E. Dowd, A. J. Mason, M. A. McGuckin, K. D. Bruce

Microbiome And Host Health

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Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

Original language	English
Article number	5437
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep05437
Publication status	Published or Issued - 25 Jun 2014

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AU - Kozlowska, J.

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AU - Fao, M.

AU - Dowd, S. E.

AU - Mason, A. J.

AU - McGuckin, M. A.

AU - Bruce, K. D.

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AB - Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

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Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice

Abstract

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