fused-somites-like mutants exhibit defects in trunk vessel patterning

Kenna M. Shaw, Daniel A. Castranova, Van N. Pham, Makoto Kamei, Kameha R. Kidd, Brigid D. Lo, Jesus Torres-Vasquez, Alexander Ruby, Brant M. Weinstein

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20 Citations (Scopus)


We identified four mutants in two distinct loci exhibiting similar trunk vascular patterning defects in an F3 genetic screen for zebrafish vascular mutants. Initial vasculogenesis is not affected in these mutants, with proper specification and differentiation of endothelial cells. However, all four display severe defects in the growth and patterning of angiogenic vessels in the trunk, with ectopic branching and disoriented migration of intersegmental vessels. The four mutants are allelic to previously characterized mutants at the fusedsomites (fss) and beamter (bed) loci, and they exhibit comparable defects in trunk somite boundary formation. The fss locus has been shown to correspond to tbx24; we show here that bea mutants are defective in the zebrafish dlC gene. Semitic expression of known vascular guidance factors efnb2a, semaSal, and sema3a2 is aberrantly patterned in fss and bea mutants, suggesting that the vascular phenotype is due to loss of proper guidance cues provided by these factors.

Original languageEnglish
Pages (from-to)1753-1760
Number of pages8
JournalDevelopmental Dynamics
Issue number7
Publication statusPublished or Issued - Jul 2006
Externally publishedYes


  • Beamter
  • Blood vessels
  • DeltaC
  • Fused somites
  • Zebrafish

ASJC Scopus subject areas

  • Developmental Biology

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