Gastrointestinal mucositis: The role of MMP-tight junction interactions in tissue injury

Noor Al-Dasooqi; Hannah R. Wardill; Rachel J. Gibson

doi:10.1007/s12253-013-9733-y

Gastrointestinal mucositis: The role of MMP-tight junction interactions in tissue injury

Noor Al-Dasooqi, Hannah R. Wardill, Rachel J. Gibson

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.

Original language	English
Pages (from-to)	485-491
Number of pages	7
Journal	Pathology and Oncology Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s12253-013-9733-y
Publication status	Published or Issued - Jul 2014
Externally published	Yes

Keywords

Gut toxicity, Mucositis, Chemotherapy
Matrix metalloproteinases
Tight junctions

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oncology
Cancer Research

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10.1007/s12253-013-9733-y

Cite this

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title = "Gastrointestinal mucositis: The role of MMP-tight junction interactions in tissue injury",

abstract = "Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.",

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T2 - The role of MMP-tight junction interactions in tissue injury

AU - Al-Dasooqi, Noor

AU - Wardill, Hannah R.

AU - Gibson, Rachel J.

PY - 2014/7

Y1 - 2014/7

N2 - Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.

AB - Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase- dependent tight junction disruption may contribute to the pathobiology of mucositis.

KW - Gut toxicity, Mucositis, Chemotherapy

KW - Matrix metalloproteinases

KW - Tight junctions

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M3 - Review article

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AN - SCOPUS:84904110854

SN - 1219-4956

VL - 20

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EP - 491

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IS - 3

ER -

Gastrointestinal mucositis: The role of MMP-tight junction interactions in tissue injury

Abstract

Keywords

ASJC Scopus subject areas

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