Gastrointestinal Sensation; General Principles

Stuart M. Brierley; David Grundy; Luke Grundy

doi:10.1016/b978-0-12-801238-3.11111-0

Gastrointestinal Sensation; General Principles

Stuart M. Brierley, David Grundy, Luke Grundy

Visceral Pain Research Group

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Our gastrointestinal (GI) tract is innervated by an assortment of afferent nerve fibers that allow us to detect a wide variety of information, including different types of mechanical and chemical stimuli. This information is sent via the spinal cord and brainstem to higher brain regions, resulting in sensations ranging from hunger, fullness, urge and in the extreme, pain. Millions of people around the globe suffer from a variety of different diseases that affect the GI tract. Such diseases are known to cause these afferent nerve fibers to become hypersensitive to mechanical and chemical stimuli, resulting in abnormal GI tract function and pathological chronic pain.

Original language	English
Title of host publication	Encyclopedia of Gastroenterology, Second Edition
Publisher	Elsevier
Pages	701-710
Number of pages	10
ISBN (Electronic)	9780128124604
DOIs	https://doi.org/10.1016/b978-0-12-801238-3.11111-0 https://doi.org/10.1016/B978-0-12-801238-3.11111-0
Publication status	Published or Issued - 1 Jan 2019

Publication series

Name	Reference Module in Biomedical Sciences

Keywords

Chemosensation
Colon
Electrophysiology
Hypersensitivity
Inflammation
Ion channels
Mechanosensation
Microbiome
Neuroplasticity
Nociception
Pain
Receptors
Sensory afferent nerves
Small intestine
Stomach

ASJC Scopus subject areas

General Medicine

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title = "Gastrointestinal Sensation; General Principles",

abstract = "Our gastrointestinal (GI) tract is innervated by an assortment of afferent nerve fibers that allow us to detect a wide variety of information, including different types of mechanical and chemical stimuli. This information is sent via the spinal cord and brainstem to higher brain regions, resulting in sensations ranging from hunger, fullness, urge and in the extreme, pain. Millions of people around the globe suffer from a variety of different diseases that affect the GI tract. Such diseases are known to cause these afferent nerve fibers to become hypersensitive to mechanical and chemical stimuli, resulting in abnormal GI tract function and pathological chronic pain.",

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AU - Grundy, Luke

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KW - Chemosensation

KW - Colon

KW - Electrophysiology

KW - Hypersensitivity

KW - Inflammation

KW - Ion channels

KW - Mechanosensation

KW - Microbiome

KW - Neuroplasticity

KW - Nociception

KW - Pain

KW - Receptors

KW - Sensory afferent nerves

KW - Small intestine

KW - Stomach

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DO - 10.1016/b978-0-12-801238-3.11111-0

M3 - Chapter

T3 - Reference Module in Biomedical Sciences

SP - 701

EP - 710

BT - Encyclopedia of Gastroenterology, Second Edition

PB - Elsevier

ER -

Gastrointestinal Sensation; General Principles

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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