Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes

Cynthia J. Faust; Annemieke J M H Verkerk; Peter J. Wilson; C. Phillip Morris; John J. Hopwood; Ben A. Oostra; Gail E. Herman

doi:10.1016/0888-7543(92)90314-I

Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes

Cynthia J. Faust, Annemieke J M H Verkerk, Peter J. Wilson, C. Phillip Morris, John J. Hopwood, Ben A. Oostra, Gail E. Herman

Hopwood Centre For Neurobiology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-A^w-J A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.

Original language	English
Pages (from-to)	814-817
Number of pages	4
Journal	Genomics
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0888-7543(92)90314-I
Publication status	Published or Issued - Apr 1992

ASJC Scopus subject areas

Genetics

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title = "Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes",

abstract = "Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.",

author = "Faust, {Cynthia J.} and Verkerk, {Annemieke J M H} and Wilson, {Peter J.} and Morris, {C. Phillip} and Hopwood, {John J.} and Oostra, {Ben A.} and Herman, {Gail E.}",

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T1 - Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes

AU - Faust, Cynthia J.

AU - Verkerk, Annemieke J M H

AU - Wilson, Peter J.

AU - Morris, C. Phillip

AU - Hopwood, John J.

AU - Oostra, Ben A.

AU - Herman, Gail E.

PY - 1992/4

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AB - Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.

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Genetic mapping on the mouse X chromosome of human cDNA clones for the Fragile X and Hunter syndromes

Abstract

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