Abstract
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Original language | English |
---|---|
Pages (from-to) | 624-633 |
Number of pages | 10 |
Journal | Nature Genetics |
Volume | 48 |
Issue number | 6 |
DOIs | |
Publication status | Published or Issued - 1 Jun 2016 |
ASJC Scopus subject areas
- Genetics
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In: Nature Genetics, Vol. 48, No. 6, 01.06.2016, p. 624-633.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
AU - Okbay, Aysu
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AU - Jöckel, Karl Heinz
AU - Kaprio, Jaakko
AU - Kardia, Sharon L R
AU - Keltikangas-J'rvinen, Liisa
AU - Kraft, Peter
AU - Kubzansky, Laura D.
AU - Lehtim'ki, Terho
AU - Magnusson, Patrik K E
AU - Martin, Nicholas G.
AU - McGue, Matt
AU - Metspalu, Andres
AU - Mills, Melinda
AU - De Mutsert, Renée
AU - Oldehinkel, Albertine J.
AU - Pasterkamp, Gerard
AU - Pedersen, Nancy L.
AU - Plomin, Robert
AU - Polasek, Ozren
AU - Power, Christine
AU - Rich, Stephen S.
AU - Rosendaal, Frits R.
AU - Den Ruijter, Hester M.
AU - Schlessinger, David
AU - Schmidt, Helena
AU - Svento, Rauli
AU - Schmidt, Reinhold
AU - Alizadeh, Behrooz Z.
AU - SØrensen, Thorkild I A
AU - DSpector, Tim
AU - Steptoe, Andrew
AU - Terracciano, Antonio
AU - Thurik, A. Roy
AU - Timpson, Nicholas J.
AU - Tiemeier, Henning
AU - Uitterlinden, André G.
AU - Vollenweider, Peter
AU - Wagner, Gert G.
AU - Weir, David R.
AU - Yang, Jian
AU - Conley, Dalton C.
AU - Smith, George Davey
AU - Hofman, Albert
AU - Johannesson, Magnus
AU - Laibson, David I.
AU - Medland, Sarah E.
AU - Meyer, Michelle N.
AU - Pickrell, Joseph K.
AU - Esko, T'nu
AU - Krueger, Robert F.
AU - Beauchamp, Jonathan P.
AU - Koellinger, Philipp D.
AU - Benjamin, Daniel J.
AU - Bartels, Meike
AU - Cesarini, David
N1 - Publisher Copyright: © 2016 Nature America, Inc.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
UR - http://www.scopus.com/inward/record.url?scp=84964388798&partnerID=8YFLogxK
U2 - 10.1038/ng.3552
DO - 10.1038/ng.3552
M3 - Article
C2 - 27089181
AN - SCOPUS:84964388798
SN - 1061-4036
VL - 48
SP - 624
EP - 633
JO - Nature Genetics
JF - Nature Genetics
IS - 6
ER -