Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism

S. W. Serjeantson; D. Owerbach; P. Zimmet; J. Nerup; K. Thoma

doi:10.1007/BF00251889

Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism

S. W. Serjeantson, D. Owerbach, P. Zimmet, J. Nerup, K. Thoma

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Genetic factors play a major role in predisposition to diabetes in the Micronesian population of Nauru. In people aged 60 years and older, 83% of full-blooded Nauruans were diabetic compared with 17% of those with ancestral foreign admixture, as detected by HLA typing. HLA distributions also showed a small increased risk for early onset of diabetes (< 46 years) associated with HLA-Bw22 (Bw56). Variation in the restriction fragment length of DNA near the insulin gene was found, but was not associated with diabetes. The distribution in fragment lengths, previously reported in Caucasoids, was observed in healthy Polynesians, Melanesians and Micronesians.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Diabetologia
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/BF00251889
Publication status	Published or Issued - Jul 1983
Externally published	Yes

Keywords

Central Pacific
HLA-Bw22
Nauru
Type 2 diabetes
diabetes genetics
insulin gene

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/BF00251889

Cite this

@article{2d274b3a98f24ff8924e4484aaaf89f0,

title = "Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism",

abstract = "Genetic factors play a major role in predisposition to diabetes in the Micronesian population of Nauru. In people aged 60 years and older, 83% of full-blooded Nauruans were diabetic compared with 17% of those with ancestral foreign admixture, as detected by HLA typing. HLA distributions also showed a small increased risk for early onset of diabetes (< 46 years) associated with HLA-Bw22 (Bw56). Variation in the restriction fragment length of DNA near the insulin gene was found, but was not associated with diabetes. The distribution in fragment lengths, previously reported in Caucasoids, was observed in healthy Polynesians, Melanesians and Micronesians.",

keywords = "Central Pacific, HLA-Bw22, Nauru, Type 2 diabetes, diabetes genetics, insulin gene",

author = "Serjeantson, {S. W.} and D. Owerbach and P. Zimmet and J. Nerup and K. Thoma",

year = "1983",

month = jul,

doi = "10.1007/BF00251889",

language = "English",

volume = "25",

pages = "13--17",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Genetics of diabetes in Nauru

T2 - Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism

AU - Serjeantson, S. W.

AU - Owerbach, D.

AU - Zimmet, P.

AU - Nerup, J.

AU - Thoma, K.

PY - 1983/7

Y1 - 1983/7

N2 - Genetic factors play a major role in predisposition to diabetes in the Micronesian population of Nauru. In people aged 60 years and older, 83% of full-blooded Nauruans were diabetic compared with 17% of those with ancestral foreign admixture, as detected by HLA typing. HLA distributions also showed a small increased risk for early onset of diabetes (< 46 years) associated with HLA-Bw22 (Bw56). Variation in the restriction fragment length of DNA near the insulin gene was found, but was not associated with diabetes. The distribution in fragment lengths, previously reported in Caucasoids, was observed in healthy Polynesians, Melanesians and Micronesians.

AB - Genetic factors play a major role in predisposition to diabetes in the Micronesian population of Nauru. In people aged 60 years and older, 83% of full-blooded Nauruans were diabetic compared with 17% of those with ancestral foreign admixture, as detected by HLA typing. HLA distributions also showed a small increased risk for early onset of diabetes (< 46 years) associated with HLA-Bw22 (Bw56). Variation in the restriction fragment length of DNA near the insulin gene was found, but was not associated with diabetes. The distribution in fragment lengths, previously reported in Caucasoids, was observed in healthy Polynesians, Melanesians and Micronesians.

KW - Central Pacific

KW - HLA-Bw22

KW - Nauru

KW - Type 2 diabetes

KW - diabetes genetics

KW - insulin gene

UR - http://www.scopus.com/inward/record.url?scp=0020621081&partnerID=8YFLogxK

U2 - 10.1007/BF00251889

DO - 10.1007/BF00251889

M3 - Article

C2 - 6350082

AN - SCOPUS:0020621081

SN - 0012-186X

VL - 25

SP - 13

EP - 17

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this