Genome partitioning of genetic variation for height from 11,214 sibling pairs

Peter M. Visscher, Stuart Macgregor, Beben Benyamin, Gu Zhu, Scott Gordon, Sarah Medland, William G. Hill, Jouke Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma, Yao Zhong Liu, Hong Wen Deng, Grant W. Montgomery, Nicholas G. Martin

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112 Citations (Scopus)


Height has been used for more than a century as a model by which to understand quantitative genetic variation in humans. We report that the entire genome appears to contribute to its additive genetic variance. We used genotypes and phenotypes of 11,214 sibling pairs from three countries to partition additive genetic variance across the genome. Using genome scans to estimate the proportion of the genomes of each chromosome from siblings that were identical by descent, we estimated the heritability of height contributed by each of the 22 autosomes and the X chromosome. We show that additive genetic variance is spread across multiple chromosomes and that at least six chromosomes (i.e., 3, 4, 8, 15, 17, and 18) are responsible for the observed variation. Indeed, the data are not inconsistent with a uniform spread of trait loci throughout the genome. Our estimate of the variance explained by a chromosome is correlated with the number of times suggestive or significant linkage with height has been reported for that chromosome. Variance due to dominance was not significant but was difficult to assess because of the high sampling correlation between additive and dominance components. Results were consistent with the absence of any large between-chromosome epistatic effects. Notwithstanding the proposed architecture of complex traits that involves widespread gene-gene and gene-environment interactions, our results suggest that variation in height in humans can be explained by many loci distributed over all autosomes, with an additive mode of gene action.

Original languageEnglish
Pages (from-to)1104-1110
Number of pages7
JournalAmerican Journal of Human Genetics
Issue number5
Publication statusPublished or Issued - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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