Global longitudinal strain predicts long-term survival in patients with chronic ischemic cardiomyopathy

Matteo Bertini, Arnold C.T. Ng, M. Louisa Antoni, Gaetano Nucifora, See H. Ewe, Dominique Auger, Nina Ajmone Marsan, Martin J. Schalij, Jeroen J. Bax, Victoria Delgado

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142 Citations (Scopus)


Background-Left ventricular (LV) global longitudinal strain (GLS) is a measure of the active shortening of the LV in the longitudinal direction, which can be assessed with speckle-tracking echocardiography. The aims of this evaluation were to validate the prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chronic ischemic cardiomyopathy and to determine the incremental value of GLS to predict long-term outcome over other strong and well-established prognostic factors. Methods and Results-A total of 1060 patients underwent baseline clinical evaluation and transthoracic echocardiography. Median age was 66.9 years (interquartile range, 58.4, 74.2 years); 739 (70%) were men. The median follow-up duration for the entire patient population was 31 months. During the follow-up, 270 patients died and 309 patients reached the combined end point (all-cause mortality and heart failure hospitalization). Compared with survivors, patients who died (270, [25%]) had larger LV volumes (P<0.05), lower LV ejection fraction (P=0.004), higher wall motion score index (P=0.001), and greater impairment of LV GLS (P<0.001). After dichotomizing the population on the basis of the median value of LV GLS (-11.5%), patients with an LV GLS < - 11.5% had superior outcome compared with patients with an LV GLS >-11.5% (log-rank χ 2, 13.86 and 14.16 for all-cause mortality and combined end point, respectively, P<0.001 for both). On multivariate analysis, GLS was independently related to all-cause mortality (hazard ratio per 5% increase, 1.69; 95% confidence interval, 1.33-2.15; P<0.001) and combined end point (1.64; 95% confidence interval, 1.32-2.04; P<0.001). Conclusions-The assessment of LV GLS with speckle-tracking echocardiography is significantly related to long-term outcome in patients with chronic ischemic cardiomyopathy.

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalCirculation: Cardiovascular Imaging
Issue number3
Publication statusPublished or Issued - May 2012
Externally publishedYes


  • 2D speckle tracking
  • Ischemic cardiomyopathy
  • Longitudinal strain
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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