TY - JOUR
T1 - Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome
AU - Thomson, Rebecca L.
AU - Buckley, Jonathan D.
AU - Noakes, Manny
AU - Clifton, Peter M.
AU - Norman, Robert J.
AU - Brinkworth, Grant D.
N1 - Funding Information:
Supported by the National Health and Medical Research Council of Australia, grant number 401817, Canberra, Australia Capital Territory, Australia. Rebecca Thomson was funded by a postgraduate scholarship from the South Australia Department of Health.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Objective: To determine the effects of weight loss on heart rate recovery (HRR) in overweight women with polycystic ovary syndrome (PCOS). Design: A 10-week prospective clinical intervention. Setting: Clinical research unit. Patient(s): Fifty-seven overweight and obese women with PCOS (age: 29.8 ± 0.8 years; body mass index [BMI] 36.2 ± 0.7 kg/m2). Intervention(s): A dietary plan of 5-6 MJ/day (∼30% energy restricted). Main Outcome Measure(s): Heart rate recovery (defined as the reduction in heart rate after 1 minute from peak heart rate after a graded treadmill test to exhaustion), weight, waist circumference, blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, and sex steroids before and after the intervention. Result(s): The mean percentage of weight loss was (-6.7 ± 0.4%). There were significant reductions in waist circumference (-6.9 ± 0.6 cm), blood pressure (-4.9/-2.5 ± 1.2/1.2 mm Hg), fasting insulin (-3.4 ± 0.7 mU/L), fasting glucose (-0.17 ± 0.05 mmol/L), homeostasis model assessment of insulin resistance (-0.43 ± 0.09), T (-0.38 ± 0.07 nmol/L), free androgen index (-2.86 ± 0.58), and an increase in sex hormone-binding globulin [SHBG] (5.86 ± 1.12 nmol/L). The HRR improved from 30.9 ± 1.1 to 38.0 ± 1.1 beats/min and that was related to the reduction in body weight (r = -0.34) and waist circumference (r = -0.27). Conclusion(s): Weight loss in overweight and obese women with PCOS is associated with improvements in HRR, which suggests improved autonomic function. This highlights the importance of weight loss to reduce the cardiovascular disease risk in these women. Crown
AB - Objective: To determine the effects of weight loss on heart rate recovery (HRR) in overweight women with polycystic ovary syndrome (PCOS). Design: A 10-week prospective clinical intervention. Setting: Clinical research unit. Patient(s): Fifty-seven overweight and obese women with PCOS (age: 29.8 ± 0.8 years; body mass index [BMI] 36.2 ± 0.7 kg/m2). Intervention(s): A dietary plan of 5-6 MJ/day (∼30% energy restricted). Main Outcome Measure(s): Heart rate recovery (defined as the reduction in heart rate after 1 minute from peak heart rate after a graded treadmill test to exhaustion), weight, waist circumference, blood pressure, glucose, insulin, homeostasis model assessment of insulin resistance, and sex steroids before and after the intervention. Result(s): The mean percentage of weight loss was (-6.7 ± 0.4%). There were significant reductions in waist circumference (-6.9 ± 0.6 cm), blood pressure (-4.9/-2.5 ± 1.2/1.2 mm Hg), fasting insulin (-3.4 ± 0.7 mU/L), fasting glucose (-0.17 ± 0.05 mmol/L), homeostasis model assessment of insulin resistance (-0.43 ± 0.09), T (-0.38 ± 0.07 nmol/L), free androgen index (-2.86 ± 0.58), and an increase in sex hormone-binding globulin [SHBG] (5.86 ± 1.12 nmol/L). The HRR improved from 30.9 ± 1.1 to 38.0 ± 1.1 beats/min and that was related to the reduction in body weight (r = -0.34) and waist circumference (r = -0.27). Conclusion(s): Weight loss in overweight and obese women with PCOS is associated with improvements in HRR, which suggests improved autonomic function. This highlights the importance of weight loss to reduce the cardiovascular disease risk in these women. Crown
KW - Cardiovascular risk
KW - autonomic function
KW - diet
KW - exercise
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=77049090034&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2008.12.003
DO - 10.1016/j.fertnstert.2008.12.003
M3 - Article
C2 - 19147136
AN - SCOPUS:77049090034
SN - 0015-0282
VL - 93
SP - 1173
EP - 1178
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -