High-Density Lipoprotein Infusions

Kohei Takata; Belinda A. Di Bartolo; Stephen J. Nicholls

doi:10.1016/j.ccl.2017.12.012

High-Density Lipoprotein Infusions

Kohei Takata, Belinda A. Di Bartolo, Stephen J. Nicholls

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Cardiology Clinics
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.ccl.2017.12.012
Publication status	Published or Issued - May 2018
Externally published	Yes

Keywords

Atherosclerosis
Cardiovascular risk
High-density lipoproteins
Lipids

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.ccl.2017.12.012

Cite this

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title = "High-Density Lipoprotein Infusions",

abstract = "High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.",

keywords = "Atherosclerosis, Cardiovascular risk, High-density lipoproteins, Lipids",

author = "Kohei Takata and {Di Bartolo}, {Belinda A.} and Nicholls, {Stephen J.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

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doi = "10.1016/j.ccl.2017.12.012",

language = "English",

volume = "36",

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T1 - High-Density Lipoprotein Infusions

AU - Takata, Kohei

AU - Di Bartolo, Belinda A.

AU - Nicholls, Stephen J.

PY - 2018/5

Y1 - 2018/5

N2 - High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

AB - High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

KW - Atherosclerosis

KW - Cardiovascular risk

KW - High-density lipoproteins

KW - Lipids

UR - http://www.scopus.com/inward/record.url?scp=85042175643&partnerID=8YFLogxK

U2 - 10.1016/j.ccl.2017.12.012

DO - 10.1016/j.ccl.2017.12.012

M3 - Review article

C2 - 29609760

AN - SCOPUS:85042175643

SN - 0733-8651

VL - 36

SP - 311

EP - 315

JO - Cardiology Clinics

JF - Cardiology Clinics

IS - 2

ER -

High-Density Lipoprotein Infusions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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