TY - JOUR
T1 - High-Resolution Transthoracic Echocardiography of the Left Anterior Descending Coronary Artery
T2 - A Novel Noninvasive Assessment of Coronary Vasoreactivity
AU - Perry, Rebecca
AU - Joseph, Majo X.
AU - De Pasquale, Carmine G.
AU - Chew, Derek P.
AU - Yiu, Derek
AU - Aylward, Philip E.
AU - Mangoni, Arduino A.
N1 - Funding Information:
This work is supported by a CVL grant from Pfizer Australia.
PY - 2008/2
Y1 - 2008/2
N2 - Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44% ± 28% increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4% ± 6.6%, P < .001). NTG induced greater changes in both parameters (60% ± 30% increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1% ± 8.2%, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.
AB - Objectives: The study objective was to determine the effects of salbutamol and nitroglycerin (NTG) on the luminal diameter of the left anterior descending (LAD) coronary artery, as measured noninvasively by the novel technique of high-resolution transthoracic echocardiography (HRTTE). Background: Invasive studies of the coronary arteries have demonstrated vasodilatation by salbutamol and NTG. By using a novel technique of HRTTE, combined with assessment of augmentation index (AIx, a marker of peripheral arterial stiffness) by means of applanation tonometry from the radial artery (pulse wave analysis), we studied the vasomotion of the proximal LAD in healthy volunteers. Methods: Nineteen male subjects (age 31 ± 5 years, mean ± standard deviation) underwent HRTTE measurement of the wall thickness, luminal diameter, and external diameter of the proximal LAD, and AIx at baseline and 5, 10, 15, and 20 minutes after administration of inhaled salbutamol (400 μg) and, after return to baseline, sublingual NTG (300 μg). Results: Salbutamol induced a 44% ± 28% increase in LAD luminal diameter (2.8 ± 0.8 mm to 3.7 ± 0.9 mm, P < .001) and a reduction in AIx (-13.4% ± 6.6%, P < .001). NTG induced greater changes in both parameters (60% ± 30% increase in luminal diameter from baseline, 2.7 ± 0.9 mm to 4.4 ± 1.1 mm, P < .001; and reduction in AIx -24.1% ± 8.2%, P < .001). Changes in LAD diameter and AIx were related after both salbutamol (r = -0.53, P = .02) and NTG (r = -0.57, P = .01). No significant change was detected in wall thickness. Conclusion: HRTTE is able to detect the LAD coronary artery vasodilating effects of NTG and salbutamol and correlates with peripheral vascular reactivity to these vasodilators. This approach provides a useful tool for the noninvasive assessment of coronary vasoreactivity.
UR - http://www.scopus.com/inward/record.url?scp=38749131602&partnerID=8YFLogxK
U2 - 10.1016/j.echo.2007.05.019
DO - 10.1016/j.echo.2007.05.019
M3 - Article
C2 - 17628418
AN - SCOPUS:38749131602
SN - 0894-7317
VL - 21
SP - 134
EP - 138
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 2
ER -