HLA antigens in four pacific populations with non-insulin-dependent diabetes mellitus

S. W. Serjeantson; D. P. Ryan; P. Zimmet; R. Taylor; R. Cross; M. Charpin; G. Le Gonidec

doi:10.1080/03014468200005501

HLA antigens in four pacific populations with non-insulin-dependent diabetes mellitus

S. W. Serjeantson, D. P. Ryan, P. Zimmet, R. Taylor, R. Cross, M. Charpin, G. Le Gonidec

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18 Citations (Scopus)

Abstract

HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.

Original language	English
Pages (from-to)	69-84
Number of pages	16
Journal	Annals of Human Biology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/03014468200005501
Publication status	Published or Issued - 1982
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Physiology
Ageing
Genetics
Public Health, Environmental and Occupational Health

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title = "HLA antigens in four pacific populations with non-insulin-dependent diabetes mellitus",

abstract = "HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.",

author = "Serjeantson, {S. W.} and Ryan, {D. P.} and P. Zimmet and R. Taylor and R. Cross and M. Charpin and {Le Gonidec}, G.",

note = "Funding Information: We wish to thank Mrs A. Thompson for excellent technicalwork and Dr P. Ram (Fiji) and Dr D. Canteloube (Ouvea) for invaluable assistance. This work was supported, in part, by NIH Grant No. RO1 AM25446-02.",

year = "1982",

doi = "10.1080/03014468200005501",

language = "English",

volume = "9",

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TY - JOUR

T1 - HLA antigens in four pacific populations with non-insulin-dependent diabetes mellitus

AU - Serjeantson, S. W.

AU - Ryan, D. P.

AU - Zimmet, P.

AU - Taylor, R.

AU - Cross, R.

AU - Charpin, M.

AU - Le Gonidec, G.

N1 - Funding Information: We wish to thank Mrs A. Thompson for excellent technicalwork and Dr P. Ram (Fiji) and Dr D. Canteloube (Ouvea) for invaluable assistance. This work was supported, in part, by NIH Grant No. RO1 AM25446-02.

PY - 1982

Y1 - 1982

N2 - HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.

AB - HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations.

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JF - Annals of Human Biology

IS - 1

ER -

HLA antigens in four pacific populations with non-insulin-dependent diabetes mellitus

Abstract

ASJC Scopus subject areas

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