HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M. A. Kennedy; R. Gonzalez-Sarmiento; U. R. Kees; F. Lampert; N. Dear; T. Boehm; T. H. Rabbitts

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M. A. Kennedy, R. Gonzalez-Sarmiento, U. R. Kees, F. Lampert, N. Dear, T. Boehm, T. H. Rabbitts

Research output: Contribution to journal › Article › peer-review

Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

Original language	English
Pages (from-to)	8900-8904
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	20
Publication status	Published or Issued - 15 Oct 1991
Externally published	Yes

Keywords

Chromosomal translocation t(7;10)
T-cell leukemia

ASJC Scopus subject areas

General

Cite this

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title = "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24",

abstract = "A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.",

keywords = "Chromosomal translocation t(7;10), T-cell leukemia",

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T1 - HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

AU - Kennedy, M. A.

AU - Gonzalez-Sarmiento, R.

AU - Kees, U. R.

AU - Lampert, F.

AU - Dear, N.

AU - Boehm, T.

AU - Rabbitts, T. H.

PY - 1991/10/15

Y1 - 1991/10/15

N2 - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

AB - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

KW - Chromosomal translocation t(7;10)

KW - T-cell leukemia

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M3 - Article

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JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 20

ER -

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

Abstract

Keywords

ASJC Scopus subject areas

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