Abstract
This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia.
Original language | English |
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Pages (from-to) | 1463-1468 |
Number of pages | 6 |
Journal | Stem Cells |
Volume | 27 |
Issue number | 6 |
DOIs | |
Publication status | Published or Issued - Jun 2009 |
Keywords
- Bone marrow transplantation
- Cancer
- Fibroblasts
- Gastrointestinal neoplasms
- Stromal cells
ASJC Scopus subject areas
- Molecular Medicine
- Developmental Biology
- Cell Biology