TY - JOUR
T1 - Human milk fatty acids from lactating mothers of preterm infants
T2 - A study revealing wide intra- and inter-individual variation
AU - Smithers, L. G.
AU - Markrides, M.
AU - Gibson, R. A.
N1 - Funding Information:
This work was supported with grants from the Channel 7 Children's Research Funds and University of Adelaide and the National Health and Medical Research Council, including Senior Research Fellowships for M.M. and R.A.G. Tuna and soy oil capsules were donated from Clover Corporation, Sydney Australia. Clover Corporation did not have any role in the study design or conduct; data collection, management, analysis or interpretation; preparation, review or approval of the manuscript.
PY - 2010/7
Y1 - 2010/7
N2 - Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important nutrients in the preterm diet and fixed ratios have been proposed for formula. We evaluated the intra- and inter-individual variation in milk fatty acids from mothers of preterm infants involved in a randomised trial of tuna oil or placebo supplementation. Milk samples were collected every 2 weeks while infants were hospitalised and fatty acids analysed by capillary gas chromatography. DHA was higher in milk of supplemented mothers than control (% total fatty acids, mean±SD, treatment 0.9±0.4, control 0.3±0.1, p<0.0005) and ranged between 0.3-2.5% and 0.1-1.1%, respectively. AA did not differ between groups and ranged between 0.2-0.9% and 0.3-0.9%, respectively. Control mothers milk had wider AA:DHA ratio than treatment mothers (0.4-3.2 versus 0.2-2.1). Due to the wide variation in milk AA and DHA, statements recommending infant formula based on a fixed AA:DHA ratio should be re-examined.
AB - Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important nutrients in the preterm diet and fixed ratios have been proposed for formula. We evaluated the intra- and inter-individual variation in milk fatty acids from mothers of preterm infants involved in a randomised trial of tuna oil or placebo supplementation. Milk samples were collected every 2 weeks while infants were hospitalised and fatty acids analysed by capillary gas chromatography. DHA was higher in milk of supplemented mothers than control (% total fatty acids, mean±SD, treatment 0.9±0.4, control 0.3±0.1, p<0.0005) and ranged between 0.3-2.5% and 0.1-1.1%, respectively. AA did not differ between groups and ranged between 0.2-0.9% and 0.3-0.9%, respectively. Control mothers milk had wider AA:DHA ratio than treatment mothers (0.4-3.2 versus 0.2-2.1). Due to the wide variation in milk AA and DHA, statements recommending infant formula based on a fixed AA:DHA ratio should be re-examined.
KW - Arachidonic acid
KW - Docosahexaenoic acid
KW - Human milk
KW - Long-chain polyunsaturated fatty acids
UR - http://www.scopus.com/inward/record.url?scp=77953543618&partnerID=8YFLogxK
U2 - 10.1016/j.plefa.2010.02.034
DO - 10.1016/j.plefa.2010.02.034
M3 - Article
C2 - 20417081
AN - SCOPUS:77953543618
SN - 0952-3278
VL - 83
SP - 9
EP - 13
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 1
ER -