Hypericum perforatum use during pregnancy and pregnancy outcome

Line Kolding; Lars Henning Pedersen; Tine Brink Henriksen; Jørn Olsen; Luke E. Grzeskowiak

doi:10.1016/j.reprotox.2015.10.003

Hypericum perforatum use during pregnancy and pregnancy outcome

Line Kolding, Lars Henning Pedersen, Tine Brink Henriksen, Jørn Olsen, Luke E. Grzeskowiak

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated. Preterm birth did not differ across the groups. While the prevalence of malformations in the HP exposed group was slightly higher (8.1%) than observed in the control groups (3.3%; p= 0.13), this was based on only three cases and was not of any specific pattern.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Reproductive Toxicology
Volume	58
DOIs	https://doi.org/10.1016/j.reprotox.2015.10.003
Publication status	Published or Issued - 1 Dec 2015
Externally published	Yes

Keywords

Birth outcomes
Human pregnancy
Hypericum perforatun
Malformations
St. John's Wort

ASJC Scopus subject areas

Toxicology

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10.1016/j.reprotox.2015.10.003

Cite this

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abstract = "Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated. Preterm birth did not differ across the groups. While the prevalence of malformations in the HP exposed group was slightly higher (8.1%) than observed in the control groups (3.3%; p= 0.13), this was based on only three cases and was not of any specific pattern.",

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AU - Kolding, Line

AU - Pedersen, Lars Henning

AU - Henriksen, Tine Brink

AU - Olsen, Jørn

AU - Grzeskowiak, Luke E.

PY - 2015/12/1

Y1 - 2015/12/1

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AB - Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal therapies in the management of depressive illness. The aim of this study was to evaluate the potential side effects of HP during pregnancy on pregnancy outcome. Using data from the Danish National Birth Cohort (DNBC), we investigated outcomes among 38 HP exposed pregnancies compared to a group of 90,128 women. Associations between HP use and gestational age, preterm birth, birth weight, malformations and Apgar scores were investigated. Preterm birth did not differ across the groups. While the prevalence of malformations in the HP exposed group was slightly higher (8.1%) than observed in the control groups (3.3%; p= 0.13), this was based on only three cases and was not of any specific pattern.

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Hypericum perforatum use during pregnancy and pregnancy outcome

Abstract

Keywords

ASJC Scopus subject areas

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