Abstract
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
Original language | English |
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Pages (from-to) | 429-431 |
Number of pages | 3 |
Journal | Tissue Antigens |
Volume | 74 |
Issue number | 5 |
DOIs | |
Publication status | Published or Issued - Nov 2009 |
Externally published | Yes |
Keywords
- Interleukin-7 receptor alpha subunit
- Juvenile idiopathic arthritis
- Rheumatoid arthritis
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics