Imaging mass spectrometry for the assessment of drugs and metabolites in tissue

Paul J. Trim, Simona Francese, Malcolm R. Clench

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


The study of drug distribution within biological tissue is a key part of the development of new pharmaceuticals. Matrix-assisted laser desorption ionization-mass spectrometric imaging is a powerful new imaging technique that can be used to study the distribution of a diverse range of endogenous and xenobiotic compounds within biological tissue. Here, fundamental aspects of the technique, appropriate instrumentation and applications in the study of xenobiotics and metabolite distribution are described. Sample preparation issues and some of the challenges in data interpretation/handling are also discussed.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
Issue number2
Publication statusPublished or Issued - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Biochemistry
  • Medical Laboratory Technology

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