TY - JOUR
T1 - Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
AU - Hilchie, Ashley L.
AU - Wuerth, Kelli
AU - Hancock, Robert E.W.
N1 - Funding Information:
We acknowledge current funding from the Canadian Institutes for Health Research (CIHR) for our own work on these peptides. A.L.H. has a postdoctoral fellowship from CIHR, K.W. holds a Cystic Fibrosis Canada Studentship and R.E.W.H. holds a Canada Research Chair.
PY - 2013/12
Y1 - 2013/12
N2 - Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.
AB - Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense peptides, and synthetic derivatives thereof, possess clinical potential beyond the treatment of antibiotic-resistant infections. In this Review, we provide an overview of the biological activities of host defense and synthetic peptides, their mechanism(s) of action and new therapeutic applications and challenges that are associated with their clinical use.
UR - http://www.scopus.com/inward/record.url?scp=84887915050&partnerID=8YFLogxK
U2 - 10.1038/nchembio.1393
DO - 10.1038/nchembio.1393
M3 - Review article
C2 - 24231617
AN - SCOPUS:84887915050
SN - 1552-4450
VL - 9
SP - 761
EP - 768
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 12
ER -