Immunity to asexual blood stage malaria and vaccine approaches

J. Wipasa, S. Elliott, H. Xu, M. F. Good

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

The development of a malaria vaccine seems to be a definite possibility despite the fact that even individuals with a life time of endemic exposure do not develop sterile immunity. An effective malaria vaccine would be invaluable in preventing malaria-associated deaths in endemic areas, especially amongst children less than 5 years of age and pregnant women. This review discusses our current understanding of immunity against the asexual blood stage of malaria - the stage that is responsible for the symptoms of the disease - and approaches to the design of an asexual blood stage vaccine.

Original languageEnglish
Pages (from-to)401-414
Number of pages14
JournalImmunology and cell biology
Volume80
Issue number5
DOIs
Publication statusPublished or Issued - 2002
Externally publishedYes

Keywords

  • Asexual blood stage
  • Malaria
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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